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Herbert Havera Phones & Addresses

  • 26357 Acorn St, Edwardsburg, MI 49112 (269) 663-2309

Publications

Us Patents

Method For Using 3-Substituted-5-Phenyl-5-Pyridyl Hydantoins As Antiarrhythmic Agents

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US Patent:
40617602, Dec 6, 1977
Filed:
Oct 4, 1976
Appl. No.:
5/729164
Inventors:
Herbert John Havera - Edwardsburg MI
Wallace Glenn Strycker - Goshen IN
Assignee:
Miles Laboratories, Inc. - Elkhart IN
International Classification:
A61K 31445
US Classification:
424267
Abstract:
Compounds having the generic structure, ##STR1## and their nontoxic, pharmacologically acceptable salts are useful in the chemotherapy of arrhythmias in individuals for whom such therapy is indicated. In the preceding structural formula: R. sup. 1 is a 2-pyridyl, 3-pyridyl, or 4-pyridyl radical; n is an integer of the set 1-3; and R. sup. 2 is a hydrogen atom, a hydroxyl, or an equivalent alkoxyl group having from 1 to 3 carbon atoms.

Method For Increasing The Milk Clotting Activity Of Thermolabile Rhizomucor Pusillus Rennet

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US Patent:
47229004, Feb 2, 1988
Filed:
Jan 17, 1986
Appl. No.:
6/819720
Inventors:
Herbert J. Havera - Edwardsburg MI
John D. Humphreys - Elkhart IN
Assignee:
Miles Laboratories, Inc. - Elkhart IN
International Classification:
C12N 958
C12R 1785
US Classification:
435223
Abstract:
Disclosed is a method for increasing the milk clotting ability and reducing the thermal stability of microbial rennet from Rhizomucor pusillus. The method involves treating the rennet with a methionine oxidizing composition and the anhydride of a dicarboxylic organic acid.

Trans-2-Substituted-Amido-Hexahydrobenzo [A]Quinolizines

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US Patent:
43049133, Dec 8, 1981
Filed:
Oct 2, 1980
Appl. No.:
6/193150
Inventors:
Herbert J. Havera - Edwardsburg MI
Wallace G. Strycker - Goshen IN
Assignee:
Miles Laboratories, Inc. - Elkhart IN
International Classification:
C07D45506
US Classification:
546 95
Abstract:
Disclosed are trans-2-substituted-amido-hexahydrobenzo[a]quinolizines represented by the formula: ##STR1## In the above formula, R. sup. 1 and R. sup. 2 are independently --H or --OCH. sub. 3 or when taken together are ##STR2## R. sup. 3 is --H or --CH. sub. 3 and R. sup. 4 is ##STR3## These compounds, and their pharmacologically acceptable, non-toxic, acid addition salts are useful as anti-hypertensive agents.

3-Substituted -5-Phenyl-5-Pyridyl Hydantoins

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US Patent:
39949044, Nov 30, 1976
Filed:
Mar 8, 1976
Appl. No.:
5/664920
Inventors:
Herbert John Havera - Edwardsburg MI
Wallace Glenn Strycker - Goshen IN
Assignee:
Miles Laboratories, Inc. - Elkhart IN
International Classification:
C07D40114
US Classification:
2602937
Abstract:
Compounds having the generic structure, ##SPC1## And their nontoxic, pharmacologically acceptable salts are useful in the chemotherapy of arrhythmias in individuals for whom such therapy is indicated. In the preceding structural formula: R. sup. 1 is a 2-pyridyl, 3-pyridyl, or 4-pyridyl radical; n is an integer of the set 1-3; and R. sup. 2 is a hydrogen atom, a hydroxyl, or an equivalent alkoxyl group having from 1 to 3 carbon atoms.

Stabilization Of Microbial Rennet

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US Patent:
48533297, Aug 1, 1989
Filed:
Jun 27, 1988
Appl. No.:
7/214027
Inventors:
Herbert J. Havera - Edwardsburg MI
John D. Humphreys - Elkhart IN
Joan M. Jazdzewski - South Bend IN
Assignee:
Miles Inc. - Elkhart IN
International Classification:
G09B 1700
US Classification:
435183
Abstract:
Microbial rennet from Rhizomucor pusillus which has been oxidized to increase its thermal lability has a normal pH of about 5. 5 in aqueous solution. It has been discovered that the stability of such solutions can be increased by raising the pH to a level of from 6. 0 to about 8. 5.

Derivatives Of 5-(Indol-3-Yl)Hydantoin

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US Patent:
41105362, Aug 29, 1978
Filed:
Apr 18, 1977
Appl. No.:
5/788154
Inventors:
Herbert J. Havera - Edwardsburg MI
Wallace G. Strycker - Goshen IN
Assignee:
Miles Laboratories, Inc. - Elkhart IN
International Classification:
C07D41314
A61K 31535
US Classification:
544139
Abstract:
Derivatives of 5-(indol-3-yl)hydantoin characterized by the generic structural formula, ##STR1## and their pharmacologically compatible salts are useful in the treatment of cardiac arrythmias in individuals for whom such therapy is indicated. In the preceding structural formula, A is a hydrogen atom, a halogeno, alkyl, hydroxyl, or an alkoxyl radical; n is 0 or 1; R is a hydrogen atom or a phenyl group; X is a methylene, ethylene, trimethylene, or 2-hydroxytrimethylene radical; and Z is a monoalkylamino radical containing 1-4 carbon atoms, a dialkylamino radical containing 2-8 carbon atoms, a morpholino, piperid-1-yl, 4-phenyl-piperid-1-yl, or a 4-hydroxy-4-phenyl-piperid-1-yl radical.

Therapeutic Method Of Treating Cardiac Arrhythmias Utilizing 3-Substituted Diphenylhydantoins

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US Patent:
40062325, Feb 1, 1977
Filed:
Nov 15, 1974
Appl. No.:
5/524297
Inventors:
Shin Hayao - Tokyo, JA
Herbert John Havera - Edwardsburg MI
Wallace Glenn Strycker - Goshen IN
Assignee:
Miles Laboratories, Inc. - Elkhart IN
International Classification:
A61K 31495
US Classification:
424250
Abstract:
3-substituted-5,5-diphenylhydantoin derivatives in which the 5,5-diphenylhydantoin moiety is attached at C. sub. 3 by a loweralkylene bridge to a 4-phenyl-1-piperidyl, 4-hydroxy-4-phenyl-1-piperidyl, 4-phenyl-1,2,3,6-tetrahydropyridyl, 4-phenyl-1-piperazinyl, or loweralkylamino group are useful in the treatment of cardiac arrhythmias in mammals. One or both of the 5,5-diphenyl substituents optionally can be substituted in the ortho-, meta-, or para-positions with halogeno, lowerakyl, loweralkoxy, amino or nitro groups.

Thermostable Rhizomucor Rennet Having Increased Milk Clotting Activity

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US Patent:
47660740, Aug 23, 1988
Filed:
Oct 13, 1987
Appl. No.:
7/107776
Inventors:
Herbert J. Havera - Edwardsburg MI
John D. Humphreys - Elkhart IN
Assignee:
Miles Inc. - Elkhart IN
International Classification:
C12N 958
C12R 1785
US Classification:
435223
Abstract:
Disclosed is a method for increasing the milk clotting ability and reducing the thermal stability of microbial rennet from Rhizomucor pusillus. The method involves treating the rennet with a methionine oxidizing composition and the anhydride of a dicarboxylic organic acid.
Herbert J Havera from Edwardsburg, MI, age ~87 Get Report