John Michael Hofstetter

56370873, Jun 10, 1997

Mar 22, 1995

8/408767

John A. O'Neil - Mundelein IL
John M. Hofstetter - Vernon Hills IL

Abbott Laboratories - Abbott Park IL

A61M 3700

604 82

A prefilled, two-constituent system is provided with a syringe barrel having a dispensing end with an inwardly directed, stationary, piercing cannula. Within the syringe barrel is a first, sealed, collapsible container holding a first constituent at subatmospheric pressure. The first container is slidably disposed within the syringe barrel adjacent the piercing cannula. A second, sealed, collapsible container holding a liquid second constituent is slidably disposed within the syringe barrel spaced from the first container. A carrier is slidably disposed within the syringe barrel between the first and second containers. The carrier has a double-ended, hollow, piercing needle with oppositely extending first and second ends for piercing the first and second containers, respectively. A plunger is slidably mounted within the syringe barrel for applying a force to the second container.

55691935, Oct 29, 1996

Mar 22, 1995

8/408463

John M. Hofstetter - Vernon Hills IL
John A. O'Neil - Mundelein IL
Richard W. Grabenkort - Barrington IL

Abbott Laboratories - Abbott Park IL

A61M 3700

604 89

A prefilled, two-constituent system is provided with first and second containers. The first container includes a first chamber having a dispensing end. The dispensing end defines a dispensing passage communicating through the dispensing end to accommodate the dispensing of fluid from the first chamber. A movable seal is slidably disposed in the first chamber, and a first constituent is provided in the first chamber between the dispensing end and the seal. A second container includes a barrel that is sized to be disposed in the first container and that has a discharge end defining a discharge passage communicating through the discharge end to accommodate the discharge of fluid from the barrel. A plunger is slidably disposed within the barrel. A liquid second constituent is provided in the barrel between the discharge end and the plunger.

61403741, Oct 31, 2000

Jul 15, 1999

9/354017

Thomas May - Grayslake IL
John Hofstetter - Vernon Hills IL
Kathleen L. Olson - Chicago IL
Sukumaran K. Menon - Gurnee IL
Bernard A. Mikrut - Lake Bluff IL
Clayton S. Ovenshire - Park Ridge IL
Lawrence John Rhodes - Lindenhurst IL
Earl R. Speicher - Buffalo Grove IL
James R. Waterson - Gurnee IL

Abbott Laboratories - Abbott Park IL

A61K 3105

514731

The present invention is directed to a sterile pharmaceutical composition comprising a propofol containing oil-in-water emulsion formulation having as an antimicrobial agent, a member selected from the group consisting of benzyl alcohol and sodium ethylene diamine tetraacetate; benzethonium chloride; and benzyl alcohol and sodium benzoate.

61403733, Oct 31, 2000

Oct 23, 1998

9/178347

Thomas May - Grayslake IL
John Hofstetter - Vernon Hills IL
Kathleen L. Olson - Chicago IL
Sukumaran K. Menon - Gurnee IL
Bernard A. Mikrut - Lake Bluff IL
Clayton S. Ovenshire - Park Ridge IL
Lawrence John Rhodes - Lindenhurst IL
Earl R. Speicher - Buffalo Grove IL
James R. Waterson - Gurnee IL

Abbott Laboratories - Abbott Park IL

A61K 3155

514731

The present invention is directed to a sterile pharmaceutical composition comprising a propofol containing oil-in-water emulsion formulation having as an antimicrobial agent, a member selected from the group consisting of benzyl alcohol and ethylene diamine tetra acetic acid; benzethonium chloride; and benzyl alcohol and sodium benzoate.

58763724, Mar 2, 1999

Aug 21, 1997

8/916903

Richard W. Grabenkort - Barrington IL
John M. Hofstetter - Vernon Hills IL
John A. O'Neil - Mundelein IL

Abbott Laboratories - Abbott Park IL

A61M 3700

604 89

A prefilled, two-constituent system is provided with first and second containers or barrels. The first barrel includes a first chamber having a dispensing end or delivery end. The delivery end defines a dispensing passage or delivery passage communicating through the delivery end to accommodate the dispensing of fluid from the first chamber. A movable seal or reciprocable stopper is slidably disposed in the first chamber, and a first constituent is provided in the first chamber between the delivery end and the stopper. A second container or barrel is sized to be disposed in the first barrel and has a discharge end defining a discharge passage communicating through the discharge end to accommodate the discharge of fluid from the second barrel. A plunger is slidably disposed within the second barrel. A liquid second constituent is provided in the second barrel between the discharge end and the plunger.