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Marcus Altfeld Phones & Addresses

  • 241 Gray St, Arlington, MA 02476
  • Cambridge, MA
  • Boston, MA

Publications

Us Patents

Epitopes Of Human Immunodeficiency Virus-1

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US Patent:
20030219450, Nov 27, 2003
Filed:
Aug 16, 2002
Appl. No.:
10/222463
Inventors:
Bruce Walker - Milton MA, US
Marcus Altfeld - Arlington MA, US
International Classification:
A61K039/21
US Classification:
424/188100
Abstract:
The invention features an immunogenic composition containing a frequently-recognized epitope of an HIV-1 accessory protein and methods of inducing an immune response using such an epitope. The epitope peptide contains an amino acid sequence of a functionally active domain or a structural domain of the accessory protein.

Cytotoxic T-Cell Epitopes Of Hiv-1 Virus

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US Patent:
20040001845, Jan 1, 2004
Filed:
May 20, 2003
Appl. No.:
10/442909
Inventors:
Marcus Altfeld - Arlington MA, US
Xu Yu - Cambridge MA, US
Bruce Walker - Milton MA, US
Marylyn Addo - Arlington MA, US
International Classification:
A61K039/21
A61K039/00
US Classification:
424/185100, 424/188100
Abstract:
The invention provides compositions containing HIV epitopes, which are recognized by cytotoxic T lymphocytes (CTL). Such polypeptides are used in vaccines and immunotherapies. HIV-1 epitopes represent early targets in a naturally-occurring response against HIV-1 infection.

Epitopes Of Human Immunodeficiency Virus-1

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US Patent:
20060216306, Sep 28, 2006
Filed:
Dec 12, 2005
Appl. No.:
11/302312
Inventors:
Bruce Walker - Milton MA, US
Marcus Altfeld - Arlington MA, US
International Classification:
A61K 39/21
C07K 14/16
US Classification:
424188100
Abstract:
The invention features an immunogenic composition containing a frequently-recognized epitope of an HIV-1 accessory protein and methods of inducing an immune response using such an epitope. The epitope peptide contains an amino acid sequence of a functionally active domain or a structural domain of the accessory protein.

Soluble Virus-Specific T-Cell Receptor Compositions

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US Patent:
20080015139, Jan 17, 2008
Filed:
Apr 5, 2007
Appl. No.:
11/784277
Inventors:
Mathias Lichterfeld - Boston MA, US
Xu Yu - Boston MA, US
Bruce Walker - Nahant MA, US
Marcus Altfeld - Arlington MA, US
Georg Lauer - Somerville MA, US
International Classification:
A61K 38/00
A61P 43/00
C07H 21/04
C07K 14/00
C12Q 1/70
US Classification:
514002000, 435005000, 530326000, 530327000, 530328000, 536023500
Abstract:
Compositions and methods for diagnosing a viral infection and methods of inhibiting such an infection are described. The methods are based on the identification of T-cell receptor gene sequences from cytotoxic T cell clones that are specific for HIV-1 or HCV. Soluble T-cell receptor compositions that bind to HLA class I-restricted of HIV and HCV pathogens were identified and constructed.
Marcus Altfeld from Arlington, MA, age ~54 Get Report