US Patent:
20080015139, Jan 17, 2008
Inventors:
Mathias Lichterfeld - Boston MA, US
Xu Yu - Boston MA, US
Bruce Walker - Nahant MA, US
Marcus Altfeld - Arlington MA, US
Georg Lauer - Somerville MA, US
International Classification:
A61K 38/00
A61P 43/00
C07H 21/04
C07K 14/00
C12Q 1/70
US Classification:
514002000, 435005000, 530326000, 530327000, 530328000, 536023500
Abstract:
Compositions and methods for diagnosing a viral infection and methods of inhibiting such an infection are described. The methods are based on the identification of T-cell receptor gene sequences from cytotoxic T cell clones that are specific for HIV-1 or HCV. Soluble T-cell receptor compositions that bind to HLA class I-restricted of HIV and HCV pathogens were identified and constructed.