US Patent:
20090263476, Oct 22, 2009
Inventors:
Vikram Katragadda - Lawrenceville NJ, US
International Classification:
A61K 9/48
A61K 9/20
A61K 31/485
Abstract:
A composition of a rapidly disintegrating buccal dosage form containing a drug, at least one non-effervescent base such as an alkali metal or alkaline earth metal oxide or hydroxide, and a disintegrant. The base regulates the pH gradient to deliver the drug to the buccal, sublingual or oral mucosal membranes at a desired rate of absorption. The composition is micronized for uniform distribution, and the drug is converted from ionized form to unionized form, without the use of an effervescent agent.
