Carolyn R Compton

54893046, Feb 6, 1996

Apr 19, 1994

8/229732

Dennis P. Orgill - Belmont MA
Charles E. Butler - Brookline MA
Mark Barlow - Boston MA
Scott Ritterbush - Saugus MA
Ioannis V. Yannas - Newton MA
Carolyn C. Compton - Chestnut Hill MA

Brigham & Women's Hospital - Boston MA
Shriners Hospital for Crippled Children - Tampa FL
Massachusetts Institute of Technology - Cambridge MA
Integra LifeSciences, Corporation - Plainsboro NJ

A61F 210

623 15

The present invention relates to a method of skin regeneration of a wound or burn in an animal or human. This method comprises the steps of initially covering the wound with a collagen glycosaminoglycan matrix, allowing infiltration of the grafted GC matrix by mesenchymal cells and blood vessels from healthy underlying tissue and applying a cultured epithelial autograft sheet grown from epidermal cells taken from the animal or human at a wound free site on the animal's or human's body surface. The resulting graft has excellent take rates and has the appearance, growth, maturation and differentiation of normal skin.

57164118, Feb 10, 1998

Feb 6, 1996

8/596060

Dennis P. Orgill - Belmont MA
Charles E. Butler - Brookline MA
Mark Barlow - Boston MA
Scott Ritterbush - Saugus MA
Ioannis V. Yannas - Newton MA
Carolyn C. Compton - Chestnut Hill MA

Brigham & Womens Hospital - Boston MA
Massachusetts Institute of Technology - Cambridge MA
Shriners Hospitals for Crippled Children - Tampa FL

A61F 210

623 15

The present invention relates to a method of skin regeneration of a wound or burn in an animal or human. This method comprises the steps of initially covering the wound with a collagen glycosaminoglycan matrix, allowing infiltration of the grafted GC matrix by mesenchymal cells and blood vessels from healthy underlying tissue and applying a cultured epithelial autograft sheet grown from epidermal cells taken from the animal or human at a wound free site on the animal's or human's body surface. The resulting graft has excellent take rates and has the appearance, growth, maturation and differentiation of normal skin.

49120310, Mar 27, 1990

Oct 23, 1987

7/111667

Carolyn C. Compton - Chestnut Hill MA
Paul J. Durda - Needham MA

E. I. Du Pont de Nemours and Company - Wilmington DE

G01N 3353
G01N 33577
A61K 3900
C12N 100

435 7

A method for distinguishing between carcinomatous and/or precarcinomatous colo-rectal disease and histologically similar conditions due to diseases that are not carcinomatous or precarcinomatous comprising contacting colo-rectal tissue with an antibody that binds to blood group substance H and determining the presence of carcinomatous or precarcinomatous disease upon a finding of bound antibody, or the absence of such disease upon the finding of no bound antibody.