Inventors:
- New York NY, US
Hanze HU - New York NY, US
Dan SHAO - New York NY, US
Chao YANG - New York NY, US
International Classification:
A61K 39/00
B01J 13/10
A61K 39/39
A61P 35/00
Abstract:
A method for synthesizing cell membrane-biomimetic nanotherapeutics can include coating core particles with cell membrane materials using flash nanocomplexation (FNC). FNC is a turbulent mixing and self-assembly method that can produce cell membrane-coated nanotherapeutics in a reproducible and scalable manner. The FNC-produced cell membrane-coated particles demonstrate lower aggregation, polydispersity, and zeta potential, than nanoparticles prepared by conventional coating methods, such as conventional bulk-sonication. As such, the present method achieves more complete, homogeneous and controllable coating than conventional bulk-sonication methods.
