Inventors:
Bret Berner - Scarsdale NY
Charles Ebert - Salt Lake City UT
Gerard C. Mazzenga - New City NY
John H. Otte - Monsey NY
Assignee:
Novartis Corporation - Summit NJ
International Classification:
A61F 1302
Abstract:
A transdermal drug delivery system comprising (i) an occlusive, impermeable polymeric backing layer; (ii) a drug depot on one side thereof; (iii) a removable, occlusive covering layer over said drug depot; and (iv) an adhesive means by which said delivery system, absent said removable covering layer may be affixed to an intended patient; said drug depot containing a drug formulation comprising a transdermally administrable pharmaceutically acceptable pharmaceutically active agent or a precursor thereof, water and lower alkanol; said active agent or precursor thereof being present in a pharmaceutically effective amount; said lower alkanol and said water being present in a volume:volume ratio of from 30:70 up to less than 95:5 such that said lower alkanol, water and drug are delivered to a patient's skin, which patient has applied said system absent said removable covering layer to said patient's skin, in amounts that said drug is delivered in a transdermally administrable efficacious amount, said water has an activity at said patient's skin of about 0. 4 to about 0. 95 and said lower alkanol, at said patient's skin, has an activity of 0.