Inventors:
Daniel J. McKay - Lexington MA, US
Melissa Arbour - Pierrefonds, CA
Renee Aspiotis - Kirkland, CA
Austin Chen - San Diego CA, US
Pierre-Andre Fournier - Vaudreuil-Dorion, CA
Michel Gallant - Pierrefonds, CA
Yongxin Han - Kirkland, CA
Helene Juteau - St. Laurent, CA
Patrick Lacombe - Montreal, CA
Sebastien Laliberte - St. Lazare, CA
Sophie Lauzon - St. Lazare, CA
Carmela Molinaro - Lansdale PA, US
Paul O'Shea - Princeton NJ, US
Yeeman Ramtohul - Pierrefonds, CA
Daniel Simard - Brookline MA, US
Dwight MacDonald - L'lle Bizard, CA
Bruce Mackay - Dollard-des-Ormeaux, CA
Christophe Mellon - L'lle Bizard, CA
Krista Morley - Brossard, CA
Chit Tsui - Toronto, CA
Sarah Jennifer Dolman - New York NY, US
Greg Hughes - Scotch Plains NJ, US
Jacob Janey - New York NY, US
Assignee:
Merck Canada Inc. - Kirkland
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
A61K 31/451
C07D 401/04
C07D 401/10
C07D 211/26
C07D 211/28
C07D 401/12
A61K 31/4545
A61K 31/454
A61P 9/12
A61P 9/04
A61P 9/10
A61P 27/06
A61P 25/22
A61P 25/00
A61P 13/12
C07D 211/22
US Classification:
514318, 546236, 546194, 546199, 546234, 546232, 546211, 546229, 514317, 514322, 514331, 514326
Abstract:
The present invention relates to biaryl piperidine-based renin inhibitor compounds, and their use in treating cardiovascular events and renal insufficiency.