David E Levy

6740519, May 25, 2004

Nov 3, 1997

08/962740

David Levy - New York NY
Peter Palese - Leonia NJ
Adolfo Garcia-Sastre - New York NY
Joan Elizabeth Durbin - Columbus OH

Mount Sinai School of Medicine - New York NY
New York University - New York NY

C12N 500

435325, 4352351, 435352, 435455

The present invention is directed to immortalized STAT1-deficient mammalian cell lines. STAT1 is a signal transducer and activator of transcription that becomes phosphorylated when cells are treated with type I or type II interferons and leads to induction of specific gene expression, resulting in establishment of the antiviral state and the other known biological responses to interferons, including the inhibition of cell proliferation. Cells which lack this gene product are useful for producing high titers of viral stocks, for producing recombinant viral vectors, for testing samples, especially clinical samples for the presence of virus and for screening candidate compounds or drugs for anti-viral activity.

43379451, Jul 6, 1982

Mar 20, 1980

6/132085

David Levy - New York NY

A63F 504

273142E

A gaming apparatus in which a roulette wheel has a circular rim and a downwardly converging frustoconical bowl contained within the rim and joined thereto forming a track therewith for a roulette ball and a rotatable wheel head centered within the bowl at the bottom thereof and formed with a plurality of numbered compartments for receiving the roulette ball. An automatic roulette ball spinner having at least one guide tube is positioned along the rim for directing the roulette ball onto the track and is provided with a powered plunger for propelling the roulette ball through the guide tube. The guide tube is vertically moveable for lowering it onto the track to discharge the ball and then raising it to allow the ball to travel around the track uninterruptedly.

56482175, Jul 15, 1997

Jun 2, 1995

8/458364

David E. Levy - New York NY

New York University - New York NY

C12Q 168
G01N 3353

435 6

An oligonucleotide comprising the DNA sequence TTTCCNGGAAA (SEQ ID NO:1) in single stranded or double stranded form, or a derivative thereof, binds to transcriptional regulatory proteins induced by cytokines, growth factors or hormones. Such oligonucleotides are useful in detecting, identifying or purifying transcriptional regulatory proteins. Recombinant DNA constructs comprising the oligonucleotide sequence operably linked to a promoter and a reporter DNA sequence and cells transfected therewith are also disclosed. Also disclosed are DNA-binding proteins other than p 91 which are inducible in a cell by a cytokine, growth factor or hormone, and which, when tyrosine phosphorylated, bind to the above oligonucleotide DNA sequence.

43914420, Jul 5, 1983

Feb 2, 1982

6/345024

David Levy - New York NY

A63E 504

273142E

A gaming apparatus in which a roulette wheel has a circular rim and a downwardly converging frustoconical bowl contained within the rim and joined thereto forming a track therewith for a roulette ball and a rotatable wheel head centered within the bowl at the bottom thereof and formed with a plurality of numbered compartments for receiving the roulette ball. An automatic roulette ball spinner has a pair of guide tubes directed oppositely to one another and positioned along the rim for directing the ball tangentially onto the track. The guide tubes have a roulette ball magazine communicating therewith including respective powered plungers for propelling the ball through the guide tubes. The powered plungers are randomly activated and, in addition, the propelling force of the powered plungers is randomly adjusted. The plungers are actuated either electromagnetically or pneumatically.

56164890, Apr 1, 1997

Feb 24, 1995

8/394191

David E. Levy - New York NY

New York University - New York NY

C07H 2104

435325

An oligonucleotide comprising the DNA sequence TTTCCNGGAAA (SEQ ID NO:1) in single stranded or double stranded form, or a derivative thereof, binds to transcriptional regulatory proteins induced by cytokines, growth factors or hormones. Such oligonucleotides are useful in detecting, identifying or purifying transcriptional regulatory proteins. Recombinant DNA constructs comprising the oligonucleotide sequence operably linked to a promoter and a reporter DNA sequence and cells transfected therewith are also disclosed. Also disclosed are DNA-binding proteins other than p91 which are inducible in a cell by a cytokine, growth factor or hormone, and which, when tyrosine phosphorylated, bind to the above oligonucleotide DNA sequence.

43322441, Jun 1, 1982

Oct 8, 1980

6/195188

David E. Levy - New York NY
Alfred Zwies - New York NY
Thomas E. Duffy - Mamaroneck NY

The Government of the United States as represented by the Secretary of
Department of Health and Human Services - Washington DC

A61M 1600

12820525

An anesthesia mask for laboratory animals comprising a supply tube having a generally conical mask at one end into which the animal's snout is inserted. Pressurized anesthesia gas is delivered through the tube and is prevented from leaking into the ambient environment by means of a second tube which concentrically surrounds the supply tube and is annularly spaced therefrom so that the space can be evacuated by a vacuum source. A holding bar is slidable transversely into the mask to hook onto the animal's incisors.

39552179, May 11, 1976

Feb 26, 1973

5/335506

David H. Levy - Forest Hills NY

A41D 2502

2150

A permanently knotted necktie comprises an elongated necktie body having a front face and a rear face, a permanent necktie knot and an extensible strap for detachably fastening the necktie around a person's neck. The permanent necktie knot and the necktie body may be formed from a single strip of material or the knot and body may be formed from separate strips of material. In the former case, the knot is formed by folding one end of the strip material back onto the front face of the body and then folding the free ends of the folded-back portion around the body and fastening them together at the rear face. In the latter case, the knot is formed by folding one end of the body strip material back onto the rear face of the body and then encircling the knot strip material around the folded-back portion and fastening together the ends of the knot strip material at the rear face.

20190351012, Nov 21, 2019

May 21, 2019

16/417755

- New York NY, US
David Levy - New York NY, US

A61K 38/15
A61K 31/551
A61P 37/00

Provided are methods of treating autoimmune diseases. The method entails administering to an individual in need of treatment one or more compositions that contain one or more inhibitors of histone deacetylatse (HDAC) and one or more inhibitors of BRD4. The method can include administering an inhibitor of binding of BRD4 to chromatin, an inhibitor of activation of BRD4 by phosphorylation, an inhibitor of signaling pathways leading to induction or increased expression of Type I interferon stimulated genes (ISG), and combinations thereof. The inhibitors may be administered at a sub-therapeutic dose, and may be administered concurrently or sequentially, in any combination.