Jian D Zhang

7787681, Aug 31, 2010

Aug 24, 2007

11/895485

Jian Zhang - New York NY, US
Alessio Salerno - Montreal, CA
Nabil Simaan - New York NY, US
Y. Lawrence Yao - New York NY, US
Gerhard Randers-Pehrson - Ossining NY, US
Guy Garty - Dobbs Ferry NY, US
Aparajita Dutta - Waltham MA, US
David J. Brenner - New York NY, US

The Trustees of Columbia University in the City of New York - New York NY

G06K 9/00

382128, 382153

Systems and methods for robotic transport are disclosed herein. In some embodiments, robotic systems for transporting biological samples include: a plurality of capillary vessels, in which each capillary vessel can contain a biological sample from a population; a receptacle that can contain the plurality of capillary vessels; a centrifuge; a first robotic device that can transport the receptacle between an input module and the centrifuge; a second robotic device that can transport the receptacle between the centrifuge and a sample harvest location; a cutting device that can cut each of the plurality of capillary vessels; a multi-well plate having a plurality of wells arranged in an array; and a third robotic device that can transfer at least one portion of each of the plurality of biological samples from each of the plurality of capillary vessels to a corresponding well in the array.

7822249, Oct 26, 2010

Aug 24, 2007

11/895417

Guy Garty - Dobbs Ferry NY, US
David J. Brenner - New York NY, US
Gerhard Randers-Pehrson - Ossining NY, US
Y. Lawrence Yao - New York NY, US
Nabil Simaan - New York NY, US
Alessio Salerno - Montreal, CA
Anubha Bhatla - Secaucus NJ, US
Jian Zhang - New York NY, US
Oleksandra V. Lyulko - New York NY, US
Aparajita Dutta - Waltham MA, US

The Trustees of Columbia University in the City of New York - New York NY

G06K 9/00

382128

Systems and methods for high-throughput radiation biodosimetry are disclosed herein. In some embodiments, a high-throughput methods of analyzing a population for radiation exposure can include, in various possible sequences: marking a first capillary designed to retain a first sample from the population with a first identifier; transporting a plurality of samples to a biodosimetry system; inputting the samples into the biodosimetry system; centrifuging the plurality of samples including the first sample wherein each sample can be retained in a capillary and the first sample can be retained in the first capillary; transferring the plurality of capillaries including the first capillary from the centrifuge to a cutting device using a robotic device; cutting the first capillary; reading the first identifier; transferring at least one portion of the first sample from the first capillary to a well in an array, wherein the array can include one or more filters in a multi-well plate; correlating the first identifier to a location of the array that includes the at least one portion of the first sample; one or more cycles of biological processing, which can include addition of a reagent and/or incubation of a selected temperature such as, for example, 37 C. , 4 C. , room temperature, and the like; sealing the array; positioning the array adjacent to an imaging element; focusing the imaging element; capturing an image of the first sample in the array; and analyzing the image to determine whether the first sample indicates a level of radiation exposure exceeding a predetermined threshold.

20110046414, Feb 24, 2011

Aug 21, 2009

12/583454

Jian Zhang - Pomona NY, US

C07C 229/04

562553

A photo-reaction of tyrosine (and small tyrosyl peptides) with cetyltrimethylamonium chloride in aqueous buffer solution is described in this patent. The reactants were exposed to simulated sun irradiance of 760 W/mat 30 C.1 C. A reddish pigment was formed with the yield ranging from 60-100% in 6 hours depending on the peptides. The pigment was believed to be a melanin crossed linked with cetyltrimethylamonium chloride. Interaction between tyrosine and neighboring nitrogen containing groups was also observed. This reaction is useful for the research of some cosmetic and pharmaceutical products. It may also have other applications if other phenols and amines are used as reactants. Some advantages of this reaction include the mild reaction condition, simple procedures, and no need for oxidants, catalysts, organic solvents and heating.

20110066160, Mar 17, 2011

Apr 3, 2009

12/934569

Nabil Simaan - Nashville TN, US
Jian Zhang - New York NY, US
Spiros Manolidis - New York NY, US

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - New York NY

A61B 19/00

606129

Systems and Methods are provided for inserting a steerable array into an anatomical structure of the body. The system includes an insertion module for holding a proximal end of the steerable array and a force sensor configured to detect force on the steerable array and to produce force information. The system includes a position sensor configured to detect a position of the insertion module and to produce position information, the position information including a lateral position along an insertion axis and a first approach angle relative to a first reference axis. The system further includes a processor configured to receive the force information from the force sensor and the position information from the position sensor. The processor outputs performance information to a user. The performance information includes an indication of a first differential approach angle relative to an insertion path plan.

20120077066, Mar 29, 2012

Sep 24, 2010

12/924272

Jian Zhang - Pomona NY, US

H01M 4/36

429101

The designs of prototype batteries are described based on some biological Fenton reactions and the photo-excitation of singlet oxygen. The biological battery consists of hydrogen peroxide (or an acid) and ferrous gluconate complexed with a second ligand. Salts such as sodium chloride or ammonium chloride are used as the electrolyte. The photochemical battery uses an aqueous paste of ferrous gluconate with an additional ligand and is irradiated by light. The power of the battery is higher by adding small amount of titanium oxide to ferrous gluconate. The power of these batteries can be increased by using higher concentration of the chemicals or connecting multiple batteries in sequence and/or in parallel. Replacing ferrous ion with cupric ions increases the current of the battery by about 20 times.

20130203835, Aug 8, 2013

Mar 7, 2011

13/582921

James L. Manley - Greenlawn NY, US
Mo Chen - New York NY, US
Charles David - New York NY, US
Jian Zhang - New York NY, US

C12N 15/113

514 44 A, 435375, 435 15

Provided herein are methods to reduce or slow down cell growth, for example in a cancer cell comprising contacting a cell with an effective amount of a combination of inhibitory RNA molecules targeting hnRNPA1, hnRNPA2 and PTB. Provided are methods to identify agents which reduce the levels of hnRNPA1, hnRNPA2 or PTB. Provided are methods to identify agents which increase ratio of PKM1/PKM2 proteins, or reduce PKM2 levels, or increase PKM1 levels.

20130273024, Oct 17, 2013

Mar 26, 2013

13/851019

Marc Labelle - Chatham NJ, US
Bei Shan - Redwood City CA, US
Jian Zhang - Foster City CA, US
Mingyue Zhou - Hayward CA, US

C12N 9/10
C07D 403/12
C07D 417/12

424 945, 51425505

The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, inflammation, thrombosis and other conditions and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide.