US Patent:
20060036331, Feb 16, 2006
Inventors:
Helen Lu - New York NY, US
Jie Jiang - New York NY, US
Clark Hung - Ardsley NY, US
Gerard Ateshian - New York NY, US
International Classification:
A61F 2/28
C12N 5/08
US Classification:
623023510, 435397000, 623023760, 623023630
Abstract:
This invention pertains to materials and methods relating to the biological fixation of one tissue type to another different tissue type, i.e., the fixation of cartilage to bone. A scaffold apparatus for osteochondral tissue engineering is described. The apparatus comprises regions of varying matrices which provide a functional interface between multiple tissue types. Further, a method for preparing the scaffold apparatus is provided. Methods for treating osteochondral tissue injury and cartilage degeneration using the scaffold apparatus are also described. In addition, a method for evaluating cell-mediated and scaffold-related parameters of development and maintenance of multiple tissue zones in vitro is described.
