US Patent:
20130345120, Dec 26, 2013
Inventors:
Kelly M. Aubart - Collegeville PA, US
Andrew B. Benowitz - Collegeville PA, US
Yuhong Fang - Eagleville PA, US
James Hoffman - Ardmore PA, US
Joseph M. Karpinski - Stowe PA, US
Andrew Nicholson Knox - Philadelphia PA, US
Xiangmin Liao - Collegeville PA, US
Donghui Qin - Collegeville PA, US
Dongchuan Shi - Collegeville PA, US
Jared T. Spletstoser - Collegeville PA, US
Assignee:
Glaxosmithkline LLC - Philadelphia PA
International Classification:
C07K 5/078
C07D 401/12
C07D 231/06
C07D 403/12
US Classification:
514 26, 5462754, 514 2191, 514 24, 514 27, 546143, 548195, 548246, 5483561, 544238, 548143, 544131, 546162, 546122, 544329, 548261, 544336, 544317, 544408, 544277, 544324, 514275, 514341, 5483794, 514403, 5142365
Abstract:
The present invention relates to a compound of Formula (I):ora pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhibition of bacterial peptide deformylase (PDF) activity.