Inventors:
Edmund Miller - Huntington NY, US
Yousef Al-Abed - Dix Hills NY, US
Yinzhong Zhang - Oakland Gardens NY, US
Kai Fan Cheng - Brooklyn NY, US
International Classification:
A61K 31/42
A61P 9/12
A61P 25/00
A61P 25/28
A61P 9/00
A61P 25/22
A61P 25/24
A61K 39/395
A61P 11/00
Abstract:
Methods are provided for treating pathologies associated with hypoxia with an MIF inhibitor. Methods are also provided for treating a subject having, or at risk for pulmonary hypertension, with an MIF inhibitor. Methods are also provided for treating a subject having, or at risk from, a CNS disorder associated with hypoxia, with an MIF inhibitor. Methods are also provided of treating severe chronic lung disease, hypoxia-induced right ventricular hypertrophy or hypoxia-induced pulmonary vascular remodeling with an MIF inhibitor. Methods of diagnosing a subject with pulmonary hypertension are also provided.