Inventors:
Steven Quay - Seattle WA, US
Shu-Chih Quay - Seattle WA, US
Najib Lamharzi - Bothell WA, US
Kristine Fry - Seattle WA, US
International Classification:
A61K 38/21
A61K 38/28
A61K 38/22
A61F 13/02
US Classification:
424448000, 514012000, 514003000, 514009000, 424085600, 424085500, 424085700
Abstract:
A composition comprising a biologically active agent and a permeation enhancing lipid wherein the permeation enhancing lipid is a platelet activating factor antagonist or a biologically inactive a platelet activating factor, and increases permeability of the biologically active agent across a tissue layer. Also disclosed is a process of increasing the permeability of a biological agent across a layer tissue comprising contacting the tissue layer with a composition comprising the biological agent and a permeation enhancing lipid wherein the permeation enhancing lipid is a platelet activating factor antagonist or a biologically inactive platelet activating factor.