Margaret S Walker from Big Sandy, TN, age 80

Polymeric Supports

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US Patent:

52928403, Mar 8, 1994

Filed:

Apr 10, 1989

Appl. No.:

7/335835

Inventors:

Steven M. Heilmann - Afton MN
Jerald K. Rasmussen - Stillwater MN
Larry R. Krepski - White Bear Lake MN
Dean S. Milbrath - Stillwater MN
Patrick L. Coleman - Minneapolis MN
Margaret M. Walker - Apple Valley MN

Assignee:

Minnesota Mining and Manufacturing Company - St. Paul MN

International Classification:

C08F 2058
C08F 2238

US Classification:

526304

Abstract:

Azlactone-functional polymer supports are useful reactive supports for the attachment of functional materials to provide novel adduct beads. The adduct beads are useful as complexing agents, catalysts, polymeric reagents, chromatographic supports, and as enzyme- or other biologically active supports. Novel carboxylate-functional polymer beads, are intermediates in the preparation of the azlactone-functional beads. Azlactone-functional supports have units of the formula: ##STR1## wherein R. sup. 1 is H or CH. sub. 3, R. sup. 2 and R. sup. 3 independently can be an alkyl group having 1 to 14 carbon atoms, a cycloalkyl group having 3 to 14 carbon atoms, an aryl group having 5 to 12 ring atoms, an arenyl group having 6 to 26 carbon and 0 to 3 S, N, and nonperoxidic O heteroatoms, or R. sup. 2 and R. sup. 3 taken together with the carbon to which they are joined can form a carbocyclic ring containing 4 to 12 ring atoms, and n is an integer 0 or 1, the azlactone functional supports having 0. 1 to 99 molar parts of crosslinking monomer incorporated therein.

Polymeric Supports

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US Patent:

54039029, Apr 4, 1995

Filed:

Jan 18, 1994

Appl. No.:

8/183063

Inventors:

Steven M. Heilmann - Afton MN
Jerald K. Rasmussen - Stillwater MN
Larry R. Krepski - White Bear Lake MN
Dean S. Milbrath - Stillwater MN
Patrick L. Coleman - Minneapolis MN
Margaret M. Walker - Apple Valley MN

Assignee:

Minnesota Mining and Manufacturing Company - St. Paul MN

International Classification:

C08F 2606
C08F22054
C08F22010

US Classification:

526260

Abstract:

Azlactone-functional polymer supports are useful reactive supports for the attachment of functional materials to provide novel adduct beads. The adduct beads are useful as complexing agents, catalysts, polymeric reagents, chromatographic supports, and as enzyme- or other biologically active supports. Novel carboxylate-functional polymer beads, are intermediates in the preparation of the azlactone-functional beads. Azlactone-functional supports have units of the formula: ##STR1## wherein R. sup. 1 is H or CH. sub. 3, R. sup. 2 and R. sup. 3 independently can be an alkyl group having 1 to 14 carbon atoms, a cycloalkyl group having 3 to 14 carbon atoms, an aryl group having 5 to 12 ring atoms, an arenyl group having 6 to 26 carbon and 0 to 3 S, N, and nonperoxidic O heteroatoms, or R. sup. 2 and R. sup. 3 taken together with the carbon to which they are joined can form a carbocyclic ring containing 4 to 12 ring atoms, and n is an integer 0 or 1, the azlactone functional supports having 0. 1 to 99 molar parts of crosslinking monomer incorporated therein.

Covalently Reactive Particles Incorporated In A Continous Porous Matrix

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US Patent:

59939354, Nov 30, 1999

Filed:

Oct 11, 1991

Appl. No.:

7/776601

Inventors:

Jerald K. Rasmussen - Stillwater MN
Steven M. Heilmann - Afton MN
Larry R. Krepski - White Bear Lake MN
Patrick L. Coleman - Minneapolis MN
Dean S. Milbrath - Stillwater MN
Margaret M. Walker - Apple Valley MN
Donald F. Hagen - Woodbury MN
Paul E. Hansen - Lake Elmo MN
John C. Campbell - St. Paul MN

Assignee:

3M Innovative Properties Company - St. Paul MN

International Classification:

B32B 700
D04H 116

US Classification:

428120

Abstract:

A composite article is provided having covalently reactive particles incorporated in a continuous, porous matrix. The reactive particles have surfaces of covalently reactive functional groups capable of directly forming covalent chemical bonds with ligands without need for an intermediate activation step. An adduct composite article is also provided comprising a continuous, porous matrix and derivatized particles dispersed therein. The derivatized particles comprise a direct, covalent reaction product of ligand with the covalently reactive particles. Methods of making and using the composite articles and adduct composite articles are also provided. Preferred covalently reactive functional groups are azlactone-functional groups of the formula: ##STR1## wherein: R. sup. 1 and R. sup. 2 independently can be an alkyl group having 1 to 14 carbon atoms, a cycloalkyl group having 3 to 14 carbon atoms, an aryl group having 5 to 12 ring atoms, an arenyl group having 6 to 26 carbon and 0 to 3 S, N, and nonperoxidic O heteroatoms, or R. sup. 1 and R. sup. 2 taken together with the carbon to which they are joined can form a carbocyclic ring containing 4 to 12 ring atoms, and n is an integer 0 or 1.