Matthew R Clark

7935658, May 3, 2011

Oct 4, 2007

11/906939

Barry Morgan - Franklin MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Bedford MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - Copenhagen, DK
Malcolm J. Kavarana - Burlington MA, US
Steffen Phillip Creaser - Cambridge MA, US
George J. Franklin - Lynn MA, US
Paolo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford MA, US

Praecis Pharmaceuticals, Inc. - Waltham MA

C40B 30/10

506 12, 506 7, 506 13, 506 23, 435 6, 435 5, 435 912, 536 231, 536 242

The present invention provides methods of synthesizing libraries of molecules comprising a functional moiety which is operatively linked to an encoding oligonucleotide. The methods generally include providing a solution comprising initiator compounds comprising an initial functional moiety which comprises n building blocks which comprise at least one reactive group, which is operatively linked to an initial oligonucleotide; dividing the solution into reaction vessels; reacting the initiator compounds in each reaction vessel with a building block comprising a complementary reactive group to form a covalent bond; and reacting the initial oligonucleotide in each aliquot with a distinct incoming oligonucleotide in the presence of an enzyme which catalyzes the ligation of the incoming oligonucleotide and the initial oligonucleotide, under conditions suitable for enzymatic ligation of the incoming oligonucleotide and the initial oligonucleotide to form an encoding oligonucleotide which identifies the structure of the functional moiety.

7972992, Jul 5, 2011

Dec 17, 2004

11/015458

Barry Morgan - Franklin MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Cambridge MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - San Francisco CA, US
Malcolm J. Kavarana - Burlington MA, US
Steffen Phillip Creaser - Cambridge MA, US
George J. Franklin - Auburn MA, US
Paolo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford MA, US

Praecis Pharmaceuticals, Inc. - Waltham MA

C40B 50/00

506 23, 506 7, 506 13, 435 6

The present invention provides methods of synthesizing a molecule comprising a functional moiety which is operatively linked to an encoding oligonucleotide. The methods include providing an initiator compound comprising an initial functional moiety comprising n building blocks, wherein the initial functional moiety comprises at least one reactive group, and is operatively linked to an initial oligonucleotide; reacting the initiator compound with a building block comprising at least one complementary reactive group, under conditions suitable for reaction of the complementary reactive group to form a covalent bond; and reacting the initial oligonucleotide with an incoming oligonucleotide corresponding to the building block in the presence of an enzyme which catalyzes ligation of the initial oligonucleotide and the incoming oligonucleotide, under conditions suitable for ligation of the incoming oligonucleotide and the initial oligonucleotide to form an encoding oligonucleotide.

7972994, Jul 5, 2011

Jun 9, 2006

11/450938

Barry Morgan - Franklin MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Cambridge MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - Copenhagen V, DK
Malcolm J. Kavarana - Burlington MA, US
Steffen Phillip Creaser - Cambridge MA, US
George J. Franklin - Auburn MA, US
Paulo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford MA, US

GlaxoSmithKline LLC - Philadelphia PA

C40B 50/16

506 31, 506 7, 506 13, 506 23, 506 25, 506 30, 435 6, 435 912, 536 231, 530300, 530350

The present invention provides methods of synthesizing libraries of molecules comprising a functional moiety which is operatively linked to an encoding oligonucleotide, wherein the encoding oligonucleotide comprises a capping sequence containing degenerate nucleotides. The methods generally include providing a solution comprising initiator compounds comprising an initial functional moiety comprising n building blocks which is operatively linked to an initial oligonucleotide; dividing the solution into reaction vessels; reacting the initiator compounds in each reaction vessel with a building block comprising a complementary reactive group to form a covalent bond; and reacting the initial oligonucleotide in each aliquot with a distinct incoming oligonucleotide in the presence of an enzyme which catalyzes the ligation of the incoming oligonucleotide and the initial oligonucleotide, under conditions suitable for enzymatic ligation of the incoming oligonucleotide and the initial oligonucleotide to form an encoding oligonucleotide.

7989395, Aug 2, 2011

Oct 23, 2006

11/584880

Barry Morgan - Franklin MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Bedford MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - Copenhagen V, DK
Malcolm J. Kavarana - Burlington MA, US
Steffen Phillip Creaser - Cambridge MA, US
George J. Franklin - Lynn MA, US
Paolo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford MA, US

GlaxoSmithKline LLC - Philadelphia PA

C40B 50/16

506 31, 506 23, 506 16, 506 5, 435 6, 435 912, 536 231, 536 242

The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.

8119798, Feb 21, 2012

Aug 1, 2007

12/375184

Matthew Clark - Bedford MA, US

GlaxoSmithKline LLC - Philadelphia PA

C07D 251/70
C07D 251/54
A61K 31/53
A61P 19/02

544196, 544197, 544198, 514245

Compounds of formula (I) and (II) are disclosed, as well as methods for their identification, their preparation, pharmaceutical compositions containing them, and their use in treating disease. The compounds inhibit the production of TNF-alpha and interleukins (IL) by the inhibition of p38 kinase. They are useful in the treatment of inflammation and arthritis.

8138338, Mar 20, 2012

Jul 27, 2007

12/375164

Matthew Clark - Bedford MA, US

GlaxoSmithKline LLC - Philadelphia PA

C07D 251/70
C07D 251/54
A61K 31/53
A61P 19/02

544196, 544197, 544198, 514245

The present invention provides, at least in part, compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein Z, Z, Z, R, x, y, R, R, R, R, R, Rand Rare described herein, as well as methods for their identification, their preparation, pharmaceutical compositions containing them, and their use as Aurora A kinase inhibitors in treatment, e. g. , of cancer and other proliferative disorders.

8410028, Apr 2, 2013

Mar 18, 2011

13/051314

Barry Morgan - Franklin MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Cambridge MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - Copenhagen V, DK
Malcolm J. Kavarana - Fairfax VA, US
Steffan Phillip Creaser - Cambridge MA, US
George J. Franklin - Auburn MA, US
Paolo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford WA, US

GlaxoSmithKline LLC - Philadelphia PA

C40B 50/08
C40B 50/06
C40B 50/10

506 27, 506 26, 506 28

The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

8598089, Dec 3, 2013

Mar 4, 2011

13/040674

Barry Morgan - Franklin MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Cambridge MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - Copenhagen V, DK
Malcolm J. Kavarana - Fairfax VA, US
Steffan Phillip Creaser - Cambridge MA, US
George J. Franklin - Auburn MA, US
Paolo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford MA, US

GlaxoSmithKline LLC - Philadelphia PA

C40B 40/06
C12P 19/34

506 16, 536 221, 536 243

The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.