Michael Medrano Phones & Addresses
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Corona, CA
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Eastvale, CA
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Lake Elsinore, CA
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Montebello, CA
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Pueblo, CO
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San Marcos, CA
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San Diego, CA
Business Records
Name / Title
Company / Classification
Phones & Addresses
MM
Esm Communications, LLC
Textbook Locators, LLC
Locating Used Textbooks for K-12
Locating Used Textbooks for K-12
125 N Aspan Ave, Duarte, CA 91702
Publications
Us Patents
Native Trre: Protein Implicated In Tnf Receptor Shedding For Treating Arthritis And Inflammation
View pageUS Patent:
20070148130, Jun 28, 2007
Filed:
Nov 1, 2006
Appl. No.:
11/591996
Inventors:
Tetsuya Gatanaga - Irvine CA, US
Michael Medrano - Phillips Ranch CA, US
Ronald Niece - Tustin CA, US
Michael Medrano - Phillips Ranch CA, US
Ronald Niece - Tustin CA, US
International Classification:
A61K 48/00
A61K 38/19
A61K 38/17
A61K 38/19
A61K 38/17
US Classification:
424085100, 514012000, 514044000
Abstract:
This disclosure provides a new family of proteins implicated in causing the release of TNF receptors and other cytokine receptors from the surface of cells involved in inflammation. Receptor releasing activity was isolated and purified from a monocyte cell line, and sequenced to deduce the gene and protein structure of several different metalloproteases. The information provided in this disclosure enables the user to prepare recombinant protein or expression vectors that will cause receptor release in vivo, thus preventing signal transduction and blocking the effect of incoming cytokines. Medicaments containing cytokine receptor releasing activity are described for use in treating rheumatoid arthritis and other conditions mediated by inflammatory cytokines. The proteins of this invention are all relatively small single-chain molecules, and are therefore easier to use and more cost-effective than other currently marketed biological anti-inflammatory agents.