Quan V Nguyen

7049151, May 23, 2006

Mar 6, 2002

10/092926

Quan Nguyen - Pleasant Hill CA, US
Yong Song - San Pablo CA, US

Bio-Rad Laboratories, Inc. - Hercules CA

G01N 33/543

436518, 436523, 436524, 435 71, 435 792, 435973

A method and kit for simultaneous detection and/or determination of a plurality of modified proteins in a sample. The method comprises: a) contacting the sample under mild protein denaturation conditions with a plurality of first antibodies capable of binding to a specific target protein, the first antibodies being immobilized on solid support material, each first antibody being differentiable from others by a differentiation parameter, whereby the first antibodies bind to respective target proteins present in the sample; b) removing unbound materials from the locus of the first antibodies; c) contacting the materials from step (b) with one or more second antibodies, each of which is specific to a class or subclass of modified proteins or with a plurality of second antibodies, each of which is specific to a modified protein, so as to bind the second antibody or antibodies to modified proteins in the sample; and d) detecting and/or determining a plurality of modified proteins in the sample. The kit comprises a plurality of primary antibodies immobilized on solid support material, one or more buffers for lysing and for washing cellular material samples to be assayed, an assay buffer for conducting the assay, the buffer containing a sulfate or sulfonate detergent, and one or more second antibodies specific to the modified proteins.

7271886, Sep 18, 2007

Nov 17, 2003

10/716176

Frank Witney - Oakland CA, US
Gary McMaster - Ann Arbor MI, US
Quan Nguyen - San Ramon CA, US
Steve Chen - Fremont CA, US

Panomics, Inc. - Fremont CA

G01J 1/00

356213, 356218, 435 5, 2504581

Uncaging devices that can be used to uncage photoactivatable caged components are provided. Consistent, uniform and/or high throughput processing of reactions and assays that include caged components is provided. Masked multiwell plates that can be used for uncaging photoactivatable caged components are provided. Methods and apparatus for initiating assays involving caged components are provided.

7376032, May 20, 2008

Jun 1, 2006

11/421497

Lam Van Nguyen - Cupertino CA, US
Quan Nguyen - Cupertino CA, US

QUALCOMM Incorporated - San Diego CA

G11C 7/02

365210, 365214, 36518909

A dummy SRAM cell for use in a dummy bit line circuit uses the same transistors as used in a standard SRAM cell, which includes first and second subsets of transistors configured as first and second bit line output circuits. The dummy SRAM cell includes the same first and second subsets of transistors, with the first transistors configured as a dummy bit line output circuit having substantially the same electrical characteristics as the first bit line output circuit of the standard SRAM cell. Further, the second transistors, which are not otherwise needed for the dummy SRAM cell function, are reconfigured as a voltage tie circuit for the dummy bit line output. Using the second transistors for this purpose obviates the need to add additional transistors to form a voltage tie circuit for configuring the dummy bit line output circuit as a load or driver for the dummy bit line.

7541193, Jun 2, 2009

Nov 17, 2003

10/716174

Quan Nguyen - San Ramon CA, US
Gary McMaster - Ann Arbor MI, US

Panomics, Inc. - Fremont CA

G01N 21/76

436172, 436164, 435183, 435193

A number of caged (e. g. , photoactivatable) compositions are provided, for example, caged enzyme sensors, caged binding sensors, caged nucleic acid probes, caged interfering RNAs, caged antisense nucleic acids, caged ribozymes, caged biomolecular analogs, caged transcription factors, caged antibodies, caged molecular decoys, and caged aptamers. Compositions comprising a plurality of caged components are also provided, as are labeled and optionally caged modulators. Also provided are kits for making the caged compositions and methods for making and for using the caged compositions. Related systems and devices are also provided (e. g. , an uncaging device that can trigger photoactivatable assays and optionally detect signals from the assays).

7551271, Jun 23, 2009

Aug 13, 2007

11/893012

Frank Witney - Oakland CA, US
Gary McMaster - Ann Arbor MI, US
Quan Nguyen - San Ramon CA, US
Steve Chen - Fremont CA, US

Panomics, Inc. - Fremont CA

G01J 1/00

356213, 356218, 435 5, 2504581

Uncaging devices that can be used to uncage photoactivatable caged components are provided. Consistent, uniform and/or high throughput processing of reactions and assays that include caged components is provided. Masked multiwell plates that can be used for uncaging photoactivatable caged components are provided. Methods and apparatus for initiating assays involving caged components are provided.

20020137097, Sep 26, 2002

Dec 13, 2001

10/017788

Quan Nguyen - Pleasant Hill CA, US
Aiguo Zhang - Hayward CA, US

Bio-Rad Laboratories, Inc. - Hercules CA

G01N033/53
G01N033/543

435/007100, 436/518000

The present invention provides standard diluents for use in multiplex assays comprising a biological fluid that normally includes two or more different target analytes but that is substantially free of the two or more different target analytes, as well as kits and methods relating to the standard diluent. The standard diluents of the invention provide an accurate and reliable means to calibrate the amount of multiple target analytes in a single assay.

20030108453, Jun 12, 2003

Dec 7, 2001

10/012190

Quan Nguyen - Pleasant Hill CA, US
Diana Davis - Sacramento CA, US

Bio-Rad Laboratories, Inc. - Hercules CA

B01L003/14

422/102000

Various functions for maintenance, calibration and validation of an automated instrument that is capable of performing multiple simultaneous assays using fluorescence detection and microscopic beads as a solid phase are provided by a single block that is inserted into the instrument in place of a sample plate. The block contains several different sets of wells, all appropriately labeled, for the retention of various liquids and bead suspensions, including different sets for the different functions.

20050059028, Mar 17, 2005

Nov 17, 2003

10/716393

Quan Nguyen - San Ramon CA, US
Gary McMaster - Ann Arbor MI, US

C12Q001/68
C07H021/02
A61K048/00

435006000, 514044000, 536023100

Methods of using labeled interfering RNAs to detect and/or quantitate target mRNAs in cells are provided. Related compositions, systems, and kits are also provided. Caged interfering RNAs (e.g., photoactivatable interfering RNAs), methods of using such caged RNAs, and related systems and kits are also provided. Methods and compositions for introducing interfering RNAs into cells, using RNAs covalently associated with protein transduction domains and/or lipids, are provided. Also provided are methods and compositions for selectively attenuating expression of a target mRNA by controlling expression of an interfering RNA.