Robert C Petersen

52962229, Mar 22, 1994

Mar 24, 1992

7/856866

Robert V. Petersen - Murray UT
Tsung-Min Hsu - Union City CA
Han-Chen Lee - Salt Lake City UT
Don Christy - Albany NY

University of Utah - Salt Lake City UT

A61K 3754

424 9463

A percutaneous drug delivery method and enhancement composition are disclosed. The method comprises applying an enzyme preparation containing suitable amounts of non-enzyme permeation enhancers, such as lactam compounds (e. g. 1-substituted-azacycloheptan-2-one), and propylene glycol to a localized area of skin for a predetermined amount of time to enhance that area of skin's permeability to selected drug(s); occluding the area of skin during the application; and then applying the selected drug(s) to the area of skin to allow the drug to penetrate through the skin and into the circulatory system of the animal. Greatly enhanced penetration of chemicals through the skin results from the described treatment.

55342604, Jul 9, 1996

Mar 21, 1994

8/216210

Robert V. Petersen - Murray UT
Tsung-Min Hsu - Union City CA
Han-Chen Lee - Salt Lake City UT
Don Christy - Albany NY

University of Utah - Salt Lake City UT

A61F 1300

424448

A percutaneous drug delivery method and enhancement composition are disclosed. The method comprises applying an enzyme preparation containing suitable amounts of non-enzyme permeation enhancers, such as lactam compounds (e. g. 1-substituted-azacycloheptan-2-one), and propylene glycol to a localized area of skin for a predetermined amount of time to enhance that area of skin's permeability to selected drug(s); occluding the area of skin during the application; and then applying the selected drug(s) to the area of skin to allow the drug to penetrate through the skin and into the circulatory system of the animal. Greatly enhanced penetration of chemicals through the skin results from the described treatment.

51568462, Oct 20, 1992

Oct 10, 1991

7/773766

Robert V. Petersen - Murray UT
Tsung-Min Hsu - St. Louis MO

University of Utah - Salt Lake City UT

A61F 1300

424443

A percutaneous drug delivery system, method, and kit are disclosed. The method comprises applying an enzyme preparation to a localized area of skin for a predetermined amount of time to enhance that area of skin's permeability to selected drugs, occluding the area of skin during the application, and then applying the selected drug(s) to the area of skin to allow the drug to penetrate through the skin and into the circulatory system of the animal. Greatly enhanced penetration of chemicals through the skin results from the enzyme treatment.

47254270, Feb 16, 1988

Mar 13, 1984

6/589152

H. DeWayne Ashmead - Fruit Heights UT
Robert V. Petersen - Salt Lake City UT

Albion International, Inc. - Clearfield UT

A61L 904
A61K 3159
A61K 3128
A61K 3130

424 44

Flavored, effervescent, water soluble compositions containing water-soluble and oil-soluble vitamins and amino acid chelated minerals in bioavailable form are contained in a composition consisting of 20-30% of a vitamin blend consisting of water-soluble and oil-soluble vitamins adsorbed on a lactose carrier containing a minor amount of propylene glycol, 5-25% of one or more amino acid chelated minerals selected from the group consisting of calcium, magnesium, iron, zinc, copper and manganese, 20-45% citric acid, 5-25% of one or more alkali or alkaline earth metal bicarbonates or carbonates, 1-5% flavoring agent, 0. 5-2% of a sweetening agent and sufficient additional lactose carrier to provide the desired vitamin and mineral content per unit dosage which will normally vary between about 2 and 6 grams. When dissolved in water a flavored, lightly carbonated drink is provided which will contain in soluble bioavailable form between about 50 to 100% of the U. S. RDA of one or more vitamins contained in a dosage unit of the composition and between about 20 to 50% of the U. S.

58402837, Nov 24, 1998

Aug 15, 1997

8/921771

James L. Sorenson - Salt Lake City UT
Robert V. Petersen - Murray UT

Sorenson Pharmaceutical, Inc. - Salt Lake City UT

A61K 704
A61K 3843

424 61

A nail-permeable medication means is disclosed for delivering a medicament through nails, claws, hoofs, or other similar hardened tissue of dermal derivation. The nail-permeable medication means includes a proteolytic enzyme component which facilitates permeation of substances through the hardened nail or keratin tissue, and also includes a medicament component selected to treat a specific disease. The nail-permeable medication means is particularly useful for treating onychomycosis of the fingernail or toenail, and avoids the need for more drastic therapeutic modalities, such as removal of the nail.

59723173, Oct 26, 1999

Aug 6, 1998

9/130132

James L. Sorenson - Salt Lake City UT
Robert V. Petersen - Murray UT

Sorenson Pharmaceutical, Inc. - Salt Lake City UT

A61K 704
A61K 3843

424 61

A nail-permeable medication means is disclosed for delivering a medicament through nails, claws, hoofs, or other similar hardened tissue of dermal derivation. The nail-permeable medication means includes a proteolytic enzyme component which facilitates permeation of substances through the hardened nail or keratin tissue, and also includes a medicament component selected to treat a specific disease. The nail-permeable medication means is particularly useful for treating onychomycosis of the fingernail or toenail, and avoids the need for more drastic therapeutic modalities, such as removal of the nail.