US Patent:
20080181874, Jul 31, 2008
Inventors:
Alexander Kharazi - San Diego CA, US
International Classification:
A61K 48/00
US Classification:
424 9321, 424 933, 424 937
Abstract:
The invention provides, in part, novel cell compositions derived from tumor cell lines. Included are an AKCV-1 cell line deposited under ATCC ______, an AKCV-1-GM cell deposited under ATCC ______, and an AKCV-1 cell that is transfected with interferon alpha. Also provided is a cell composition comprising a tumor cell line that is transfected with GMCSF, and a tumor cell line that is transfected with interferon alpha. The invention further relates to therapeutic and non-therapeutic uses of the novel cell lines. Therapeutic applications of the presently disclosed cell lines include the use of the cell lines as whole cell cancer vaccines.