Inventors:
Aloka B. Bandara - Blacksburg VA, US
Stephen M. Boyle - Blacksburg VA, US
Nammalwar Sriranganathan - Blacksburg VA, US
Gerhardt G. Schurig - Blacksburg VA, US
Assignee:
Virginia Tech Intellectual Properties, Inc. - Blacksburg VA
International Classification:
A61K 39/10
C12N 15/74
Abstract:
A recombinant, attenuated strain of or with a deficiency in carboxyl-terminal protease activity or tail-specific protease activity can be used as a vaccine for the prevention or treatment of Brucellosis. Prior exposure to the species is identified by detecting a genetic sequence for carboxyl-terminal (i. e. tail-specific) protease activity in a biological sample.
