Inventors:
William Morrow Clark - Philadelphia PA
Ivan Lantos - Wayne PA
Robert John Mills - Norristown PA
Lendon Norwood Pridgen - Collegeville PA
Ann Marie Tickner - Norristown PA
Assignee:
SmithKline Beecham Corporation - Philadelphia PA
International Classification:
C07D31770
US Classification:
549432, 568630, 568648, 568649, 568656
Abstract:
Invented is an improved process for preparing aromatic ring-fused cyclopentane derivatives. Preferred compounds prepared by this invention are indane carboxylates and cyclopentanopyridine derivatives. The most preferred compounds prepared by this invention are (+)(1S, 2R, 3S)-3-[2-(2-hydroxyeth-1-yloxy)-4-methoxyphenyl]-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylic acid and pharmaceutically acceptable salts thereof and (+)(1S, 2R, 3S)-3-(2-carboxymethoxy-4-methoxyphenyl)-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylic acid and pharmaceutically acceptable salts thereof. Also invented are novel intermediates useful in preparing these compounds.