US Patent:
20130345392, Dec 26, 2013
Inventors:
Tamas Bartfai - San Diego CA, US
Bruno Conti - San Diego CA, US
Avijit Ghosh - New Haven CT, US
John Hadcock - Dedham MA, US
Olivia Osborn - Solana Beach CA, US
Jean Schaefer - Niantic CT, US
Iustin Tabarean - San Diego CA, US
International Classification:
C07K 14/47
Abstract:
This application discloses novel EDN3-like polypeptides. One such short polypeptide is EDN3 97-140, which is a 44 amino acid peptide that stimulates GLP-1 secretion in enteric cells and inhibits gluconeogenesis in hepatic cells. EDN3 97-140, as well as other EDN3-like polypeptides provided herein may be used in the study and treatment of a number of indications, including the treatment of metabolic disorders such as obesity and diabetes.
