Bernard D Loev

6599937, Jul 29, 2003

Sep 25, 2000

09/669013

Edward Neiss - New Canaan CT
Bernard Loev - Medford NJ

Beacon Laboratories, Inc. - Phoenix MD

A01N 3700

514533

The invention relates to methods of modulating gene expression in a hematopoietic cell or augmenting hematopoiesis in a host, as well as methods of treating, preventing, or ameliorating disorders affecting hematopoiesis level in a host, by administering to the host or the hematopoietic cell an effective amount of a compound of formula (I).

44915829, Jan 1, 1985

Mar 3, 1983

6/471594

Bernard Loev - Scarsdale NY
Howard Jones - Ossining NY
John T. Suh - Greenwich CT

USV Pharmaceutical Corporation - Tarrytown NY

C07D40306
A61K 31495

424250

1,4-Dihydropyridine carboxylic acid esters of the formula: ##STR1## wherein Ar is heteroaryl selected from the group consisting of thiophene, furan, pyridine, thiazole, pyrimidine, pyrrole, benzofuran, quinoline and benzothiophene, cycloalkyl having from 3 to 7 carbon atoms, naphthyl, indanyl, indenyl, tetrahydronaphthyl, or a radical of the formula ##STR2## wherein each of R. sub. 5, R. sub. 6 and R. sub. 7 is independently H, alkyl, phenyl, tolyl, naphthyl, halo, lower alkoxy, nitro, amino, alkylmercapto, cyano, carboxy, carbalkoxy, sulfamyl, trifluoromethyl, hydroxy, methanesulfonyl, or alkylamino and R. sub. 5 and R. sub. 6 when taken together, form a methylenedioxy; Z is alkylene containing 1 to about 5 carbon atoms in the principal chain; each R. sub. 1 is independently hydrogen, alkyl or alkoxyalkyl, with the proviso that only one R. sub. 1 may be hydrogen; R. sub.

45230420, Jun 11, 1985

Jul 29, 1983

6/518785

Bernard Loev - Scarsdale NY
Howard Jones - Ossining NY

USV Pharmaceutical - Tuckahoe NY

C07C 3518

568824

This invention relates to novel compounds having pharmaceutical activity and having the general structure ##STR1## wherein the Z, R. sub. 1, R. sub. 2, R. sub. 3, R. sub. 4, n and m are defined within.

44761252, Oct 9, 1984

Mar 24, 1983

6/478394

Bernard Loev - Scarsdale NY
Fu-Chih Huang - Boonton NJ

USV Pharmaceutical Corporation - Tarrytown NY

A61K 31535
A61K 3154
C07D49804
C07D51304

424246

New benzobisoxazinetetrones having anti-allergic activity are described. These benzobisoxazinetetrones are represented by the following formula: ##STR1## and pharmaceutically acceptable salts thereof, wherein: X and Y are independently O, S, NH, N-alkyl or N-aryl; R. sub. 1 is H, lower alkyl, aryl, aralkyl, heteroalkyl, alkoxyalkyl, aminoalkyl or carboxyalkyl; R. sub. 2 and R. sub. 3 are independently H, OH, alkoxy, lower alkyl, aryl, aralkyl, halogen, trifluoromethyl, nitro, cyano, carboxy or sulfonamido useful in the treatment of allergies.

39564940, May 11, 1976

May 8, 1975

5/575885

Bernard Loev - Broomall PA

SmithKline Corporation - Philadelphia PA

A61K 31535

424248

Pharmaceutical compositions and methods of inhibiting gastric acid secretion by administering 2-alkoxy(and 2-amino)-3-amino-2-heterocyclic-2-thiopropanamides.

39766330, Aug 24, 1976

Jun 3, 1974

5/475699

Charles E. Berkoff - Huntingdon Valley PA
David T. Hill - North Wales PA
Bernard Loev - Broomall PA

SmithKline Corporation - Philadelphia PA

C07C11500
A61K 31655

260140R

The compounds of this invention are substituted cyano,trifluoromethylphenyl linear triazenes having pharmacological activity. In particular, these compounds have anorectic and anti-obesity activity. A preferred compound is 1,3-bis(2-cyano-5-trifluoromethylphenyl)triazene.

45349797, Aug 13, 1985

Nov 2, 1984

6/667703

Bernard Loev - Scarsdale NY
Howard Jones - Holmdel NJ

USV Pharmaceutical Corp. - Tarrytown NY

A61K 3118
A61K 3119
A61K 3123

514529

Polyene compounds represented by the general formulae ##STR1## in which: R and R. sub. 1 are each hydrogen or an alkyl group of from 1 to 5 carbon atoms; R. sub. 2 is an alkyl group of from 1 to 5 carbon atoms; R. sub. 3 is hydroxyl, alkoxy of from 1 to 5 carbon atoms, NH. sub. 2, NHR. sub. 2 or NR. sub. 2 R. sub. 2 and Z is a cycloalkyl, cycloalkenyl or cycloalkdienyl group substituted with from 0 to 5 alkyl groups, a keto group or a hydroxyl group or a phenyl group substituted with from 0 to 4 hydroxy, alkoxy, alkyl, aryloxy, aralkyloxy or trifluoromethyl groups or halogen atoms or combinations thereof and the pharmaceutically-acceptable salts thereof. The foregoing compounds have been found to be effective in the treatment of psoriasis, inflammatory conditions and allergic responses.

43025919, Nov 24, 1981

Sep 2, 1980

6/182885

James R. Shroff - Riverside CT
Bernard Loev - Scarsdale NY

USV Pharmaceutical Corporation - Tuckahoe NY

C07D40104
C07D40114
C07D21182

546257

Iminobenzyl dihydropyridines of the formula ##STR1## wherein, each R is alkyl, alkenyl, alkynyl, cycloalkyl, aryl, aralkyl, sulfonamido, halogen, alkoxy, alkenyloxy, alkynyloxy, cyano, hydroxy, acyloxy, nitro, amino, alkylmercapto, alkylamino, alkanoylamino, carbalkoxyamino, carboxy, methanesulfonyl, carbalkoxy or trifluoromethyl; each R. sub. 4 is lower alkoxy; each R. sub. 2 is lower alkyl; and R. sub. 3 is alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclic or ##STR2## wherein R is as previously defined; have anti-hypertensive activity.