US Patent:
20130317087, Nov 28, 2013
Inventors:
Lynne E. Maquat - Rochester NY, US
Chenguang Gong - Rochester NY, US
Assignee:
UNIVERSITY OF ROCHESTER - Rochester NY
International Classification:
C12Q 1/68
US Classification:
514 44 A, 436501, 506 9, 435 612, 536 245
Abstract:
Disclosed are compositions and methods for identifying binding sites of targets of Staul-mediated mRNA decay; methods and compositions for treating subjects with conditions resulting from Staul-mediated mRNA decay, and method of screening for therapeutic agents. Also disclosed is the new pathway as a means for cells to down-regulate the expression of Staul-binding mRNAs.