US Patent:
20210284709, Sep 16, 2021
Inventors:
- Seattle WA, US
- Cambridge MA, US
Christopher BORGES - Cambridge MA, US
Stephen Michael BURLEIGH - Seattle WA, US
Alexandra CROFT - Seattle WA, US
Stephen Jacob GOLDFLESS - Seattle WA, US
David Jeffrey HUSS - Seattle WA, US
Yue JIANG - Seattle WA, US
Timothy G. JOHNSTONE - Seattle WA, US
David KOPPSTEIN - Seattle WA, US
Hieu NGUYEN - Seattle WA, US
Christopher Heath NYE - Seattle WA, US
Haley PEPER - Seattle WA, US
Blythe D. SATHER - Seattle WA, US
Sonia TIMBERLAKE - Seattle WA, US
Dean Y. TOY - Seattle WA, US
Queenie VONG - Seattle WA, US
Gordon Grant WELSTEAD - Cambridge MA, US
James SISSONS - Seattle WA, US
Assignee:
Juno Therapeutics, Inc. - Seattle WA
Editas Medicine, Inc. - Cambridge MA
International Classification:
C07K 14/725
A61P 35/00
A61P 31/20
A61K 35/17
C12N 9/22
C12N 15/11
C12N 15/90
Abstract:
Provided are binding molecules, such as TCRs or antigen binding fragments thereof and antibodies and antigen-binding fragments thereof, such as those that recognize or bind human papilloma virus (HPV) 16, including HPV 16 E6 and HPV 16 E7. Also provided are engineered cells containing such binding molecules, compositions containing the binding molecules or engineered cells, and methods of treatment, such as administration of the binding molecules, engineered cells, or compositions.