Inventors:
Edward Mroszczak - Mountain View CA
Richard Runkel - Palo Alto CA
Assignee:
Syntex (U.S.A.) Inc. - Palo Alto CA
International Classification:
A61K 3140
C07D48704
Abstract:
Compounds of the formula: R'--CH. sub. 2 --S--A wherein: R' is hydrogen, alkyl, --COOH or its pharmaceutically acceptable salts, --alkylene--COOH or its pharmaceutically acceptable salts, --alkylene-SO. sub. 2 H or its pharmaceutically acceptable salts, --alkylene-SO. sub. 3 H or its pharmaceutically acceptable salts, or --alkylene CH. sub. 2 OH; and A is the acyl moiety of a pharmaceutically acceptable carboxylic acid, said acid having antiinflammatory properties; are gastrointestinal tract sparing drugs for antiinflammatory pharmaceuticals.