US Patent:
20110281908, Nov 17, 2011
Inventors:
Aiming Sun - Atlanta GA, US
Ganesh Thota - Decatur GA, US
Jaeki Min - Marietta GA, US
Pahk Thepchatri - Atlanta GA, US
Yuhong Du - Atlanta GA, US
James P Snyder - Atlanta GA, US
Dennis C. Liotta - Atlanta GA, US
Assignee:
EMORY UNIVERSITY - Atlanta GA
International Classification:
A61K 31/47
A61K 31/4709
C07D 401/12
C07D 215/38
A61P 35/00
US Classification:
514313, 546171, 514311, 546162
Abstract:
Novel classes of molecular chaperone Heat shock protein 90 (Hsp90) inhibitors and methods for making these classes are provided herein. These compounds are useful in treating and preventing cancer and other Hsp90-related diseases, such as inflammation and neurodegenerative disorders. Also provided herein are methods of treating and preventing cancer and other Hsp90 related disease. The methods include administering to a subject a therapeutically effective amount of an Hsp90 inhibitor.
