Resumes
Resumes
Gene Wild Phones & Addresses
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17020 Joliet Rd, Westfield, IN 46074
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Indianapolis, IN
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4321 156Th St, Zionsville, IN 46077 (317) 873-4726
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Carmel, IN
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4321 W 156Th St, Zionsville, IN 46077
Business Records
Name / Title
Company / Classification
Phones & Addresses
Principal
Wild's Apple Farm
Fruit Tree Orchard
Fruit Tree Orchard
4321 W 156 St, Zionsville, IN 46077
Publications
Us Patents
Process For Producing 20-Dihydro-20-Deoxy-23-Demycinosyltylosin
View pageUS Patent:
43048560, Dec 8, 1981
Filed:
Nov 10, 1980
Appl. No.:
6/205539
Inventors:
Richard H. Baltz - Indianapolis IN
Herbert A. Kirst - Indianapolis IN
Gene M. Wild - Indianapolis IN
Eugene T. Seno - Norwich, GB2
Herbert A. Kirst - Indianapolis IN
Gene M. Wild - Indianapolis IN
Eugene T. Seno - Norwich, GB2
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
C12P 1962
C12N 120
C12R 154
C12N 120
C12R 154
US Classification:
435 76
Abstract:
20-Dihydro-20-deoxy-23-demycinosyltylosin (DH-DO-DMT), 20-dihydro-20-deoxy-5-O-mycaminosyltylonolide (DH-DO-OMT), specified acyl ester derivatives, and their acid addition salts are useful intermediates and antibacterial agents. Methods of preparing DH-DO-DMT and DH-DO-OMT by fermentation of Streptomyces fradiae and the microorganism S. fradiae ATCC 31733 are included.
Purification Of Glycopeptide Antibiotics Using Non-Functional Resins
View pageUS Patent:
44407530, Apr 3, 1984
Filed:
Mar 15, 1982
Appl. No.:
6/358399
Inventors:
Mack H. McCormick - Westlake OR
Gene M. Wild - Indianapolis IN
Gene M. Wild - Indianapolis IN
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
A61K13500
US Classification:
424124
Abstract:
Purification of glycopeptide antibiotics actaplanin and vancomycin by adsorption on non-functional resins followed by elution of the antibiotic from the resin with aqueous solvents.
Antibiotic A-4696 Factor G
View pageUS Patent:
46379819, Jan 20, 1987
Filed:
Mar 26, 1984
Appl. No.:
6/593015
Inventors:
Charles L. Hershberger - New Palestine IN
Kurt E. Merkel - Mooresville IN
Robert E. Weeks - Indianapolis IN
Gene M. Wild - Indianapolis IN
Kurt E. Merkel - Mooresville IN
Robert E. Weeks - Indianapolis IN
Gene M. Wild - Indianapolis IN
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
C12P 1960
C12P 1956
C12N 120
C12R 1045
C12P 1956
C12N 120
C12R 1045
US Classification:
435 75
Abstract:
Glycopeptide antibiotic A-4696G is produced by culturing Actinoplanes missouriensis mutant strain ATCC 31681 under submerged aerobic fermentation conditions, and is recovered from the fermentation broth by resin adsorption and chromatographic purification. A-4696G inhibits the growth of bacteria pathogenic to man and animals and also enhances the growth of ruminants by increasing feed utilization.
Method For Producing 2"'-O-Demethyltylosin
View pageUS Patent:
50631551, Nov 5, 1991
Filed:
Mar 28, 1988
Appl. No.:
7/173860
Inventors:
Karen L. Cox - Martinsville IN
Eugene T. Seno - Indianapolis IN
Gene M. Wild - Indianapolis IN
Eugene T. Seno - Indianapolis IN
Gene M. Wild - Indianapolis IN
Assignee:
Eli Lilly and Company - Indianpolis IN
International Classification:
C12N 121
C12N 1552
C12N 1576
C12P 1962
C12N 1552
C12N 1576
C12P 1962
US Classification:
435 76
Abstract:
The present invention discloses a method for producing a novel antibiotic, 2"'-O-demethyltylosin. The novel antibiotic, utilizing recombinant DNA technology, can be produced from a transformed mutant of a tylosin producing microorganism. By transforming for example Streptomyces fradiae GS 16 with plasmid pHJL284, the transformant can produce 2"'-O-demethyltylosin. Streytomyces fradiae GS16 is a tylosin producing species that contain a mutation in the tylE gene found in the tylosin biosynthetic pathway. The tylE gene codes for demethylmacrocin 2"'-O-methyltransferase enzyme (DMOMT), the enzyme that methylates the 2-hydroxyl position of the 6-deoxyallose moiety. Plasmid pHJL284 contains the cloned tylF gene which codes for the macrocin 3"'-O-methyltransferase enzxyme (MOMT), the enzyme that methylates the 3"'-hydroxyl position, but it does not contain the tylE gene. Transformation of S. fradiae GS16 with plasmid pHJL284 results in increased copies of the tylF gene in the absence of the tylE gene, therefore allowing an increased rate of methylation of the 3"'-hydroxyl position in the absence of the methyl group at the 2"'-hydroxyl position.
Process For Producing 20-Dihydro-20-Deoxy-23-De(Mycinosyloxy)Tylosin
View pageUS Patent:
44231482, Dec 27, 1983
Filed:
Jul 2, 1982
Appl. No.:
6/394599
Inventors:
Gene M. Wild - Indianapolis IN
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
C12P 1962
C12R 154
C07H 1708
C12R 154
C07H 1708
US Classification:
435 76
Abstract:
20-Dihydro-20-deoxy-23-de(mycinosyloxy)tylosin (20-deoxo-DMOT), specified 2'-acyl ester derivatives, and their acid addition salts are useful intermediates and antibacterial agents. Methods of preparing 20-deoxo-DMOT and 5-O-mycaminosyltylactone by fermentation of Streptomyces fradiae ATCC 31733 are included.
Antibiotic A-4696 Factor G
View pageUS Patent:
44617232, Jul 24, 1984
Filed:
Sep 29, 1982
Appl. No.:
6/426493
Inventors:
Charles L. Hershberger - New Palestine IN
Kurt E. Merkel - Mooresville IN
Robert E. Weeks - Indianapolis IN
Gene M. Wild - Indianapolis IN
Kurt E. Merkel - Mooresville IN
Robert E. Weeks - Indianapolis IN
Gene M. Wild - Indianapolis IN
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
C07C10352
US Classification:
2601125R
Abstract:
Glycopeptide antibiotic A-4696G is produced by culturing Actinoplanes missouriensis mutant strain ATCC 31681 under submerged aerobic fermentation conditions, and is recovered from the fermentation broth by resin adsorption and chromatographic purification. A-4696G inhibits the growth of bacteria pathogenic to man and animals and also enhances the growth of ruminants by increasing feed utilization.
Mycarosyltylactone
View pageUS Patent:
42999537, Nov 10, 1981
Filed:
Jul 29, 1980
Appl. No.:
6/173312
Inventors:
Robert L. Hamill - Greenwood IN
Gene M. Wild - Indianapolis IN
Gene M. Wild - Indianapolis IN
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
C07H 1708
C07D31300
C07D31300
US Classification:
536 17R
Abstract:
Mycarosyltylactone (5-O-mycarosyl-20-dihydro-20,23-dideoxytylonolide) which has the formula: ##STR1## 3,4'-diacyl ester derivatives of mycarosyltylactone wherein each of said esters is an ester of a monocarboxylic acid or a hemi-ester of a dicarboxylic acid, each of 1 to 18 carbon atoms, and the corresponding 3-acyl ester derivatives of tylactone, are useful intermediates in the preparation of macrolide antibiotics. New methods for making tylactone and the 3-acyl ester derivatives of tylactone are provided.
20-Dihydro-20-Deoxy-23-Demycinosyltylosin And Process For Its Production
View pageUS Patent:
44195087, Dec 6, 1983
Filed:
Sep 28, 1981
Appl. No.:
6/305930
Inventors:
Richard H. Baltz - Indianapolis IN
Herbert A. Kirst - Indianapolis IN
Gene M. Wild - Indianapolis IN
Eugene T. Seno - Norwich, GB2
Herbert A. Kirst - Indianapolis IN
Gene M. Wild - Indianapolis IN
Eugene T. Seno - Norwich, GB2
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
C07H 1708
C12P 1962
C12P 1962
US Classification:
536 71
Abstract:
20-Dihydro-20-deoxy-23-demycinosyltylosin (DH-DO-DMT), 20-dihydro-20-deoxy-5-O-mycaminosyltylonolide (DH-DO-OMT), specified acyl ester derivatives, and their acid addition salts are useful intermediates and antibacterial agents. Methods of preparing DH-DO-DMT and DH-DO-OMT by fermentation of Streptomyces fradiae and the microorganism S. fradiae ATCC 31733 are included.