Georgi E Hvichia

20070072290, Mar 29, 2007

Jul 17, 2002

10/587053

Georgi Hvichia - Philadelphia PA, US

C12M 1/12

435308100, 435288500, 422101000, 435293100

The invention relates to microscale cell separating apparatus which are able to separate cells on the basis of size of the cells, interaction of the cells with surfaces of the apparatus, or both. The apparatus comprises a stepped or sloped separation element () interposed between an inlet region () and an outlet region () of a void that can be filled with fluid. The void can be enclosed within a cover () and fluid flow through the void engages cells with the separation element. Only cells which have (or can deform to have) a characteristic dimension smaller than or equal to the distance between a step and the cover or body can pass onto or past a step. Modifications of surfaces within the apparatus can also inhibit passage of cells onto or past a step.

20120052567, Mar 1, 2012

Jun 28, 2011

13/170369

Georgi HVICHIA - Philadelphia PA, US

Parsortix, Inc. - Philadelphia PA

C12N 5/00
C12M 1/00
C12N 1/20

435325, 4352521, 4352831

The invention relates to microscale cell separating apparatus which are able to separate cells on the basis of size of the cells, interaction of the cells with surfaces of the apparatus, or both. The apparatus comprises a stepped or sloped separation element () interposed between an inlet region () and an outlet region () of a void that can be tilled with fluid. The void can be enclosed within a cover () and fluid flow through the void engages cells with the separation element. Only cells which have (or can deform to have) a characteristic dimension smaller than or equal to the distance between a step and the cover or body can pass onto or past a step. Modifications of surfaces within the apparatus can also inhibit passage of cells onto or past a step.

20190217294, Jul 18, 2019

Mar 20, 2019

16/358897

- King of Prussia PA, US
Georgi HVICHIA - Philadelphia PA, US

B01L 3/00
C12N 5/09
G01N 33/574
G01N 15/02
G01N 33/49
C12Q 1/24

The disclosure relates to an apparatus for segregating particles on the basis of their ability to flow through a stepped passageway. At least some of the particles are unable to pass through a narrower passageway bounded by a segregating step, resulting in segregation of the particles. The breadth of the leading edge of at least one step of the apparatus is significantly greater than the overall width of the passageway in which the step occurs, permitting high and rapid sample throughput. The apparatus and methods described herein can be used to segregate particles of a wide variety of types. By way of example, they can be used to segregate circulating tumor cells from a human blood sample.

20180126378, May 10, 2018

Nov 21, 2017

15/819052

- Philadelphia PA, US
Georgi HVICHIA - Philadelphia PA, US

B01L 3/00
C12N 5/09
G01N 33/49

The disclosure relates to an apparatus for segregating particles on the basis of their ability to flow through a stepped passageway. At least some of the particles are unable to pass through a narrower passageway bounded by a segregating step, resulting in segregation of the particles. The breadth of the leading edge of at least one step of the apparatus is significantly greater than the overall width of the passageway in which the step occurs, permitting high and rapid sample throughput. The apparatus and methods described herein can be used to segregate particles of a wide variety of types. By way of example, they can be used to segregate circulating tumor cells from a human blood sample.

20180045708, Feb 15, 2018

Oct 23, 2017

15/790981

- Philadelphia PA, US
Georgi HVICHIA - Philadelphia PA, US

G01N 33/49
B01L 3/00
C12N 5/09

The disclosure relates to an apparatus for segregating particles on the basis of their ability to flow through a stepped passageway. At least some of the particles are unable to pass through a narrower passageway bounded by a segregating step, resulting in segregation of the particles. The breadth of the leading edge of at least one step of the apparatus is significantly greater than the overall width of the passageway in which the step occurs, permitting high and rapid sample throughput. The apparatus and methods described herein can be used to segregate particles of a wide variety of types. By way of example, they can be used to segregate circulating tumor cells from a human blood sample.

20170157609, Jun 8, 2017

Feb 16, 2017

15/434223

- Philadelphia PA, US
Georgi HVICHIA - Philadelphia PA, US

B01L 3/00

The disclosure relates to an apparatus for segregating particles on the basis of their ability to flow through a stepped passageway. At least some of the particles are unable to pass through a narrower passageway bounded by a segregating step, resulting in segregation of the particles. The breadth of the leading edge of at least one step of the apparatus is significantly greater than the overall width of the passageway in which the step occurs, permitting high and rapid sample throughput. The apparatus and methods described herein can be used to segregate particles of a wide variety of types. By way of example, they can be used to segregate circulating tumor cells from a human blood sample.

20170160263, Jun 8, 2017

Feb 16, 2017

15/434249

- Philadelphia PA, US
Georgi HVICHIA - Philadelphia PA, US

G01N 33/49
C12N 5/09
B01L 3/00

The disclosure relates to an apparatus for segregating particles on the basis of their ability to flow through a stepped passageway. At least some of the particles are unable to pass through a narrower passageway bounded by a segregating step, resulting in segregation of the particles. The breadth of the leading edge of at least one step of the apparatus is significantly greater than the overall width of the passageway in which the step occurs, permitting high and rapid sample throughput. The apparatus and methods described herein can be used to segregate particles of a wide variety of types. By way of example, they can be used to segregate circulating tumor cells from a human blood sample.

20160376553, Dec 29, 2016

Nov 13, 2013

14/079319

- Philadelphia PA, US
Georgi HVICHIA - Philadelphia PA, US

C12N 5/0735
B01D 35/30

The invention relates to microscale cell separating apparatus which are able to separate cells on the basis of size of the cells, interaction of the cells with surfaces of the apparatus, or both. The apparatus comprises a stepped or sloped separation element () interposed between an inlet region () and an outlet region () of a void that can be tilled with fluid. The void can be enclosed within a cover () and fluid flow through the void engages cells with the separation element. Only cells which have (or can deform to have) a characteristic dimension smaller than or equal to the distance between a step and the cover or body can pass onto or past a step. Modifications of surfaces within the apparatus can also inhibit passage of cells onto or past a step.