Gerald M Edelman

7183395, Feb 27, 2007

Jan 26, 2001

10/182329

Vincent P. Mauro - San Diego CA, US
Gerald M. Edelman - La Jolla CA, US
Stephen A. Chappell - Del Mar CA, US
Frederick S. Jones - Cardiff CA, US
Geoffrey Owens - San Diego CA, US
Robyn Meech - San Diego CA, US

The Scripps Research Institute - La Jolla CA

C07H 21/02
C07H 21/04
C12N 15/00
C12N 15/09
C12N 15/63
C12N 15/70
C12N 15/74

536 231, 536 241, 4353201

Provided are methods of identifying oligonucleotides having transcriptional or translational activity by integrating the oligonucleotide into a eukaryotic cell genome such that the oligonucleotide is operatively linked to an expressible polynucleotide, and detecting a change in expression of the expressible polynucleotide due to the operatively linked oligonucleotide. Also provided are vectors useful for identifying an oligonucleotide having transcriptional or translational regulatory activity according to a method of the invention. In addition, isolated synthetic transcriptional or translational regulatory elements identified according to a method of the invention are provided, as are kits, which contain a vector useful for identifying a transcriptional or translational regulatory element, or an isolated synthetic transcriptional or translational regulatory element or plurality of such elements. Also provided are isolated transcriptional regulatory elements.

7456273, Nov 25, 2008

Nov 29, 2006

11/607131

Vincent P. Mauro - San Diego CA, US
Gerald M. Edelman - La Jolla CA, US
Stephen A. Chappell - Del Mar CA, US
Frederick S. Jones - Cardiff CA, US
Geoffrey Owens - San Diego CA, US
Robyn Meech - San Diego CA, US

The Scripps Research Institute - La Jolla CA

C07H 21/04
C07H 21/02
C12Q 1/68

536 241, 536 231, 435 6

Provided are methods of identifying oligonucleotides having transcriptional or translational activity by integrating ilie oligonucleotide into a eukaryotic cell genome such that the oligonucleotide is operatively linked to an expressible polynucleotide, and detecting a change in expression of the expressible polynucleotide due to the operatively linked oligonucleotide. Also provided are vectors useful for identifying an oligonucleotide having transcriptional or translational regulatory activity according to a method of the invention. In addition, isolated synthetic transcriptional or translational regulatory elements identified according to a method of the invention are provided, as are kits, which contain a vector useful for identifying a transcriptional or translational regulatory element, or an isolated synthetic transcriptional or translational regulatory element or plurality of such elements. Also provided are isolated transcriptional regulatory elements.

7467115, Dec 16, 2008

Jul 12, 2005

11/179371

Gerald M. Edelman - La Jolla CA, US
Jeffrey L. Krichmar - Cardiff-by-the-Sea CA, US
Douglas A. Nitz - Del Mar CA, US

Neurosciences Research Foundation, Inc. - San Diego

G06N 5/00

706 15, 706 23

A brain-based device (BBD) having a physical mobile device NOMAD controlling and under control by a simulated nervous system. The simulated nervous system is based on an intricate anatomy and physiology of the hippocampus and its surrounding neuronal regions including the cortex. The BBD integrates spatial signals from numerous objects in time and provides flexible navigation solutions to aid in the exploration of unknown environments. As NOMAD navigates in its real world environment, the hippocampus of the simulated nervous system organizes multi-modal input information received from sensors on NOMAD over timescales and uses this organization for the development of spatial and episodic memories necessary for navigation.

7468275, Dec 23, 2008

Jan 26, 2001

10/182327

Vincent P. Mauro - San Diego CA, US
Gerald M. Edelman - La Jolla CA, US
Stephen A. Chappell - Del Mar CA, US
Geoffrey Owens - San Diego CA, US
Jason K. Pinkstaff - Cardiff CA, US
Leslie Krushel - Denver CO, US
Wei Zhou - San Diego CA, US

The Scripps Research Institute - La Jolla CA

C12N 15/63
C12N 15/85
C12N 5/10
C07H 21/02
C07H 21/04
A61K 48/00

435325, 4353201, 536 231, 536 241

Synthetic and isolated translational regulatory elements, including oligonucleotides that have translational enhancing activity, internal ribosome entry site (IRES) activity, or translational inhibitory activity, and multimers of such translational regulatory elements are provided. In addition, compositions that include such translational regulatory elements are provided, as are methods of using the translational regulatory elements.

7519452, Apr 14, 2009

Apr 13, 2005

11/105019

Anil K. Seth - San Diego CA, US
Jeffrey L. McKinstry - San Diego CA, US
Gerald M. Edelman - La Jolla CA, US
Jeffrey L. Krichmar - Cardiff-by-the-Sea CA, US

Neurosciences Research Foundation, Inc. - San Diego CA

G06F 15/18
G06N 3/00
G06F 15/00
G05B 19/04

700249, 700250, 700259, 706 13, 706 44

A mobile brain-based device BBD includes a mobile base equipped with sensors and effectors (Neurally Organized Mobile Adaptive Device or NOMAD), which is guided by a simulated nervous system that is an analogue of cortical and sub-cortical areas of the brain required for visual processing, decision-making, reward, and motor responses. These simulated cortical and sub-cortical areas are reentrantly connected and each area contains neuronal units representing both the mean activity level and the relative timing of the activity of groups of neurons. The brain-based device BBD learns to discriminate among multiple objects with shared visual features, and associated “target” objects with innately preferred auditory cues. Globally distributed neuronal circuits that correspond to distinct objects in the visual field of NOMAD are activated. These circuits, which are constrained by a reentrant neuroanatomy and modulated by behavior and synaptic plasticity, result in successful discrimination of objects.

7765029, Jul 27, 2010

Sep 11, 2006

11/530685

Jason G. Fleischer - Del Mar CA, US
Botond Szatmary - Del Mar CA, US
Donald B. Hutson - San Diego CA, US
Douglas A. Moore - San Diego CA, US
James A. Snook - San Diego CA, US
Gerald M. Edelman - La Jolla CA, US
Jeffrey L. Krichmar - Cardiff-by-the-Sea CA, US

Neurosciences Research Foundation, Inc. - San Diego CA

G06N 3/02
G05B 13/00
G06F 19/00
G06E 1/00

700250, 700 48, 700 61, 700249, 700255, 700259, 706 14, 706 15, 706 16, 706 20

A brain-based device (BBD) for moving in a real-world environment has sensors that provide data about the environment, actuators to move the BBD, and a hybrid controller which includes a neural controller having a simulated nervous system being a model of selected areas of the human brain and a non-neural controller based on a computational algorithmic network. The neural controller and non-neural controller interact with one another to control movement of the BBD.

7827124, Nov 2, 2010

Dec 27, 2006

11/646930

Jeffrey L. McKinstry - San Diego CA, US
Gerald M. Edelman - La Jolla CA, US
Jeffrey L. Krichmar - Cardiff-by-the-Sea CA, US

Neurosciences Research Foundation, Inc. - San Diego CA

G06N 5/00

706 14, 706 45

A mobile brain-based device (BBD) includes a mobile platform with sensors and effectors, which is guided by a simulated nervous system that is an analogue of the cerebellar areas of the brain used for predictive motor control to determine interaction with a real-world environment. The simulated nervous system has neural areas including precerebellum nuclei (PN), Purkinje cells (PC), deep cerebellar nuclei (DCN) and an inferior olive (IO) for predicting turn and velocity control of the BBD during movement in a real-world environment. The BBD undergoes training and testing, and the simulated nervous system learns and performs control functions, based on a delayed eligibility trace learning rule.

7844556, Nov 30, 2010

Dec 9, 2008

12/331133

Gerald M. Edelman - La Jolla CA, US
Jeffrey L. Krichmar - Cardiff-by-the-Sea CA, US
Douglas A. Nitz - San Diego CA, US

Neurosciences Research Foundation, Inc. - San Diego CA

G06N 5/00

706 15, 706 45

A brain-based device (BBD) having a physical mobile device NOMAD controlling and under control by a simulated nervous system. The simulated nervous system is based on an intricate anatomy and physiology of the hippocampus and its surrounding neuronal regions including the cortex. The BBD integrates spatial signals from numerous objects in time and provides flexible navigation solutions to aid in the exploration of unknown environments. As NOMAD navigates in its real world environment, the hippocampus of the simulated nervous system organizes multi-modal input information received from sensors on NOMAD over timescales and uses this organization for the development of spatial and episodic memories necessary for navigation.