Inventors:
Scott W. Bagley - Groton CT
Theodore P. Broten - Ambler PA
Prasun K. Chakravarty - Edison NJ
Daljit S. Dhanoa - Secaucus NJ
Kenneth J. Fitch - Cranford NJ
William J. Greenlee - Teaneck NJ
Nancy Jo Kevin - Clifton NJ
Gerard R. Kieczykowski - Westfield NJ
Douglas J. Pettibone - Chalfont PA
James R. Tata - Westfield NJ
Ralph A. Rivero - Tinton Falls NJ
Thomas F. Walsh - Westfield NJ
David L. Williams - Telford PA
Jay M. Matthews - Fords NJ
Richard B. Toupence - Cranford NJ
Assignee:
Merck & Co. Inc. - Rahway NJ
International Classification:
A61K 3119
A61K 31535
C07D26530
C07C 5911
Abstract:
Phenoxyphenylacetic acids and derivatives of the general structural formula I ##STR1## have endothelin antagonist activity and are useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, endotoxic shock, benign prostatic hyperplasia, inflammatory diseases including Raynaud's disease and asthma.