Israel C Kleinberg

5989525, Nov 23, 1999

Feb 19, 1998

9/026132

Israel Kleinberg - Smithtown NY
Ana Maria Acevedo - Caracas, VE
Robi Chatterjee - South Setanket NY

The Research Foundation of State University of New York - Stony Brook NY

A61K 716
A61K 3310

424 49

The present invention relates to oral compositions containing anti-caries agents distributed in an oral vehicle. In particular, the present invention provides oral compositions containing calcium, arginine and a cariostatic anion distributed in an oral vehicle. A method for preparing oral compositions containing anti-caries agents is also provided by the present invention. A method of reducing dental caries is described which comprises delivering a therapeutically effective amount of an oral composition containing calcium, arginine and a cariostatic anion into the oral cavity.

6409992, Jun 25, 2002

Jun 10, 1998

09/077249

Israel Kleinberg - Smithtown NY
Milroy Codipilly - Coram NY

The Research Foundation of State University of New York - Stony Brook NY

A61K 716

424 49, 424 53, 424613, 424614, 424615

The present invention relates to an oral composition containing a zinc compound containing free available zinc ion and at least one stabilized or stable E raising compound distributed in an oral vehicle. The present invention further relates to a method of inhibiting the formation of sulfur containing anions and preventing a reduction in the E of the oral cavity. A method of reducing oral malodor and gingivitis and periodontitis is also provided by this invention.

6423300, Jul 23, 2002

Feb 17, 2000

09/506662

Israel Kleinberg - Smithtown NY
Milroy Codipilly - Coram NY

The Research Foundation of State University of New York - Stony Brook NY

A61K 716

424 49, 424 48, 424 53, 424401, 424614, 514900, 514901, 514902, 514494

The present invention relates to an oral composition containing a zinc compound containing free available zinc ion and at least one stabilized or stable E raising compound distributed in an oral vehicle. The present invention further relates to a method of inhibiting the formation of sulfur containing anions and preventing a reduction in the E of the oral cavity. A method of reducing oral malodor and gingivitis and periodontitis is also provided by this invention.

6436370, Aug 20, 2002

Feb 15, 2000

09/504264

Israel Kleinberg - Smithtown NY
Ana Marie Acevedo - Las Palmas, VE
Robi Chatterjee - Centereach NY

The Research Foundation of State University of New York - Stony Brook NY

A61K 716

424 49, 424401, 424 52, 424687

The present invention relates to compositions and methods for calcifying dental tissue, e. g. , preventing or treating dental hypersensitivity. An oral composition of arginine bicarbonate and calcium carbonate promotes the formation of dentinal tubule plugs aided by combining calcium and phosphate in the fluid. In a specific example, an arginine bicarbonate/calcium carbonate mixture blocked dentinal tubules in a model system. In addition to treating dentinal sensitivity, the compositions and methods of the invention provide for calcifying exposed tooth pulp, calcifying the base or all of a pit or fissure in a tooth, and treating a carious lesion.

6524558, Feb 25, 2003

Aug 27, 2001

09/940723

Israel Kleinberg - Smithtown NY
Ana Marie Acevedo - Caracas, VE
Robi Chatterjee - Centereach NY

The Research Foundation of the State University of New York - Stony Brook NY

A61K 716

424 49, 424687, 514835

The present invention relates to compositions and methods for calcifying dental tissue, e. g. , preventing or treating dental hypersensitivity. An oral composition of arginine bicarbonate and calcium carbonate promotes the formation of dentinal tubule plugs aided by combining calcium and phosphate in the fluid. In a specific example, an arginine bicarbonate/calcium carbonate mixture blocked dentinal tubules in a model system. In addition to treating dentinal sensitivity, the compositions and methods of the invention provide for calcifying exposed tooth pulp, calcifying the base or all of a pit or fissure in a tooth, and treating a carious lesion.

6929790, Aug 16, 2005

Jun 24, 2002

10/179312

Israel Kleinberg - Smithtown NY, US
Milroy Codipilly - Coram NY, US

The Research Foundation of State University of New York - Stony Brook NY

A61K007/16
A61K007/20
A61K033/16
A61K033/40

424 49, 424 53, 424613, 424614, 424615

The present invention relates to an oral composition containing a zinc compound containing free available zinc ion and at least one stabilized or stable Eraising compound distributed in an oral vehicle. The present invention further relates to a method of inhibiting the formation of sulfur containing anions and preventing a reduction in the Eof the oral cavity. A method of reducing oral malodor and gingivitis and periodontitis is also provided by this invention.

20030133885, Jul 17, 2003

Dec 23, 2002

10/328389

Israel Kleinberg - Smithtown NY, US
Ana Acevedo - Las Palmas, VE
Robi Chatterjee - Centereach NY, US

The Reseaarch Foundation of the State University of New York

A61K007/16
A61K007/22

424/054000

The present invention relates to compositions and methods for calcifying dental tissue, e.g., preventing or treating dental hypersensitivity. An oral composition of arginine bicarbonate and calcium carbonate promotes the formation of dentinal tubule plugs aided by combining calcium and phosphate in the fluid. In a specific example, an arginine bicarbonate/calcium carbonate mixture blocked dentinal tubules in a model system. In addition to treating dentinal sensitivity, the compositions and methods of the invention provide for calcifying exposed tooth pulp, calcifying the base or all of a pit or fissure in a tooth, and treating a carious lesion.

20080233054, Sep 25, 2008

Aug 8, 2007

11/836041

Israel Kleinberg - Smithtown NY, US
Ana Marie Acevedo - Caracas, VE
Robi Chatterjee - Centereach NY, US

Research Foundation of State of University of New York - Albany NY

A61K 8/43
A61K 8/55
A61K 9/68
A23L 1/30
A23L 1/236

424 48, 424 49, 424 57, 426648, 426548

The present invention relates to compositions and methods for calcifying dental tissue, e.g., preventing or treating dental hypersensitivity. An oral composition of arginine bicarbonate and calcium carbonate promotes the formation of dentinal tubule plugs aided by combining calcium and phosphate in the fluid. In a specific example, an arginine bicarbonate/calcium carbonate mixture blocked dentinal tubules in a model system. In addition to treating dentinal sensitivity, the compositions and methods of the invention provide for calcifying exposed tooth pulp, calcifying the base or all of a pit or fissure in a tooth, and treating a carious lesion.