Inventors:
C. Jeffrey Brinker - Albuquerque NM, US
Paul N. Durfee - Albuquerque NM, US
Jason Townson - Albuquerque NM, US
Yu-Shen Lin - Seattle WA, US
Stanley Shihyao Chou - Albuquerque NM, US
Jacob Erstling - Orlando FL, US
International Classification:
A61K 9/127
A61K 47/62
A61K 47/69
A61P 31/14
A61P 35/02
Abstract:
The present disclosure is directed to methods of producing monosized protocells from monosized mesoporous silica nanoparticles (mMSNPs) and their use for targeted drug delivery formulations and systems and for biomedical applications. The present disclosure is also directed in part to a multilamellar or unilamellar protocell vaccine to deliver full length viral protein and/or plasmid encoded viral protein to antigen presenting cells (APCs) in order to induce an immunogenic response to a virus.