Janice K Pero

6551813, Apr 22, 2003

May 6, 1999

09/306615

John B. Perkins - Reading MA
Alan Sloma - Watertown MA
Janice G. Pero - Lexington MA
Randolph T. Hatch - Wellesley MA
Theron Hermann - Framingham MA
Thomas Erdenberger - Arlington MA

Roche Vitamins Inc. - Parsippany NJ

C12P 2500

4352536, 435 66

Vectors and recombinant bacteria for overproducing riboflavin, in which nucleic acid overproducing riboflavin biosynthetic proteins is introduced in the chromosome of the host organism, e. g. at multiple sites and in multiple copies per site. A rib operon having at least five genes is used to make such recombinant bacteria.

6737256, May 18, 2004

Jul 14, 1997

08/914332

Scott W. Van Arsdell - Lexington MA
R. Rogers Yocum - Lexington MA
John B. Perkins - Reading MA
Janice G. Pero - Lexington MA

Roche Vitamins Inc. - Parsippany NJ

C12P 1718

435119, 43525231, 435128, 435130, 435193, 435440, 4353201, 536 232

A method is disclosed for the increased production of biotin and the biotin precursor dethiobiotin using a bacterium that produces a lysine-utilizing DAPA aminotransferase. This method involves the use of a bacterium that is either grown in the presence of lysine or deregulated for lysine biosynthesis.

6841366, Jan 11, 2005

Sep 28, 1999

09/407728

Stanley Grant Bower - Arlington MA, US
John B. Perkins - Reading MA, US
R. Rogers Yocum - Lexington MA, US
Janice G. Pero - Lexington MA, US

DSM IP Assets B.V. - Heerlen

C12N 900

435183, 435189, 435193, 435243, 4352525, 4353201, 536 231

The invention generally provides the genes of the biotin biosynthetic operon of , and closely related species thereof, and well as constructions useful for high level production of biotin.

7091000, Aug 15, 2006

Feb 10, 2003

10/361522

John B. Perkins - Reading MA, US
Alan Sloma - Watertown MA, US
Janice G. Pero - Lexington MA, US
Randolph T. Hatch - Wellesley MA, US
Theron Hermann - Framingham MA, US
Thomas Erdenberger - Arlington MA, US

DSM Nutritional Products, Inc. - Parsippany NJ

C12P 21/00
C07H 21/04
A61K 38/16
A61K 38/43

435 681, 435 691, 435 711, 514 12, 536 232, 536 237

Vectors and recombinant bacteria for overproducing riboflavin, in which nucleic acid overproducing riboflavin biosynthetic proteins is introduced in the chromosome of the host organism, e. g. at multiple sites and in multiple copies per site. A rib operon having at least five genes is used to make such recombinant bacteria.

7244593, Jul 17, 2007

Jan 18, 2002

10/466641

R. Roger Yocum - Lexington MA, US
Thomas A. Patterson - North Attleboro MA, US
Janice G. Pero - Lexington MA, US
Theron Hermann - Kinnelon NJ, US

BASF Aktiengesellschaft

C12P 13/04

435106, 435183, 435189, 435193, 435232, 4352523

The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.

7291489, Nov 6, 2007

Jul 3, 2003

10/614333

R. Rogers Yocum - Lexington MA, US
Thomas A. Patterson - North Attleboro MA, US
Janice G. Pero - Lexington MA, US
Theron Hermann - Kinnelon NJ, US

BASF Aktiengesellschaft

C12P 13/04
C12N 9/00
C12N 1/20
C12N 15/00
C07H 21/04

435106, 435183, 435189, 435193, 435195, 4352523, 4353201, 530350, 536 232

The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.

7989187, Aug 2, 2011

Jul 3, 2003

10/520220

Rogers R. Yocum - Lexington MA, US
Thomas A. Patterson - North Attleboro MA, US
Janice G. Pero - Lexington MA, US
Theron Hermann - Kinnelon NJ, US

BASF SE - Ludwigshafen

C12P 13/04
C12N 9/00
C12N 9/10
C12N 1/20
C12N 15/00
C07H 21/04

435106, 435183, 435193, 4352523, 4353201, 536 232

The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.

8148117, Apr 3, 2012

Oct 23, 2006

12/091948

Oskar Zelder - Speyer, DE
Andrea Herold - Ludwigshafen, DE
Corinna Klopprogge - Mannheim, DE
Hartwig Schröder - Nussloch, DE
Stefan Haefner - Speyer, DE
Elmar Heinzle - Saarbruecken, DE
Christoph Wittmann - Saarbruecken, DE
Jens Kroemer - Riegelsberg, DE
Janice G. Pero - Lexington MA, US
R. Rogers Yocum - Lexington MA, US
Thomas A. Patterson - North Attleboro MA, US
Mark Williams - Revere MA, US
Theron Herman - Kinnelon NJ, US

Evonik Degussa GmbH - Essen

C12P 13/12
C12N 9/00
C12N 15/00
C12N 1/21

435113, 43525232, 435440, 435183

The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented.