US Patent:
20170145412, May 25, 2017
Inventors:
- Cambridge MA, US
Mallikarjuna R. Putta - Lexington MA, US
Jillian M. DiMuzio - Harleysville PA, US
Lakshmi Bhagat - Framingham MA, US
Sudhir Agrawal - Shrewsbury MA, US
International Classification:
C12N 15/113
A61K 45/06
A61K 31/7088
Abstract:
The present invention is directed to compounds, compositions, and methods useful for modulating NLRP3 mRNA or protein expression using gene silencing compounds comprising two or more single stranded antisense oligonucleotides that are linked through their 5′-ends to allow the presence of two or more accessible 3′-ends.