A bottled chemical handling system having an outer protective housing for supporting an inner shelving and containment module. The inner containment module is provided with a series of bottle shelves arranged at compound angles with respect to horizontal so as to prevent rolling motion of bottles stored on the shelves and to enable any spilled liquid to drain to the rear of the inner module and then down into a sump region at the lower back portion of the inner module. A drain vent interconnects the sump region within the module to the outside of the protective housing, while a fume vent provides a fluid path from the module interior to ambient. The system is provided with castors and a locking foot to facilitate transportation of the system between locations and to stabilize the system when in place. A wide variety of bottle sizes can be stored in the inner module on the angled shelves or on an additional bottom shelf.