Larry S Liebovitch

20030215866, Nov 20, 2003

May 1, 2003

10/427294

Larry Liebovitch - Boca Raton FL, US
Viktor Jirsa - Delray Beach FL, US
Lina Shehadeh - Coconut Creek FL, US

C12Q001/68
G06F019/00
G01N033/48
G01N033/50

435/006000, 702/020000

Models of different patterns of genetic interactions were formulated and used in methods to determine the architecture of genetic interactions from mRNA expression levels measured in microarray experiments. The methods can be used to screen biological systems to identify which systems are candidates for therapeutic intervention. Also provided are machine readable storage and systems for using the disclosed models and methods.

49593552, Sep 25, 1990

Mar 16, 1987

7/025959

Jorge Fischbarg - New York NY
Larry S. Liebovitch - Long Island City NY
Jan P. Koniarek - Briarcliff Manor NY

The Trustees of Columbia University in the City of New York - New York NY

A61K 3105
A61K 3140
A61K 31705
A61K 3170

514 23

This invention provides a method of inhibiting osmotic water flow across mammalian cell membranes which involves contacting the water channels of the cell membranes with an effective amount of a glucose transport blocker or of digitonin so as to inhibit osmotic water flow across the membranes. Additionally, this invention provides a method of treating a subject afflicted with a condition associated with abnormal osmotic water flow across cell membranes which comprises administering to the subject an effective amount of a glucose transport blocker or of digitonin so as to contact the water channels of the subject's cell membranes and inhibit osmotic water flow across the membranes.