Inventors:
Hidenori Mikamiyama - Osaka, JP
Chiyou Ni - Belle Mead NJ, US
Bin Shao - Richboro PA, US
Laykea Tafesse - Robbinsville NJ, US
Assignee:
Purdue Pharma L.P. - Stamford CT
Shionogi & Co., Ltd. - Osaka
International Classification:
A01N 43/40
A61K 31/445
US Classification:
514318, 514326, 544192, 544193, 544208, 544209, 544210, 544211
Abstract:
The invention relates to tetrahydropyridinyl and dihydropyrrolyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein X, Y, Z, R, R, m, and n are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.