Inventors:
Michael P. Kirkup - West Windsor NJ
Sundeep Dugar - Bridgewater NJ
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
A61K 31395
C07D20508
C07D40306
C07D40304
Abstract:
Substituted azetidinone hypocholesterolemic agents of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: Ar. sup. 1 is R. sup. 3 -substituted aryl; Ar. sup. 2 is R. sup. 4 -substituted aryl; Ar. sup. 3 is R. sup. 5 -substituted aryl; Y and Z are independently --CH. sub. 2 --, --CH(lower alkyl)-- or --C(dilower alkyl)--; A is --O--, --S--, --S(O)-- or --S(O). sub. 2 --; R. sup. 1 is --OR. sup. 6, --O(CO)R. sup. 6, --O(CO)OR. sup. 9 or --O(CO)NR. sup. 6 R. sup. 7 ; R. sup. 2 is hydrogen, lower alkyl or aryl; or R. sup. 1 and R. sub. 2 together are. dbd. O; q is 1, 2 or 3; p is 0, 1,2, 3 or 4; R. sup. 5 is 1-3 substitutes independently selected from --OR. sup. 6, --O(CO)R. sup. 6, --O(CO)OR. sup. 9, --O(CH. sub. 2). sub. 1-5 OR. sup.