Resumes
Resumes
Michalakis Savva Phones & Addresses
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Savannah, GA
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240 Sumner Ave, Roselle Park, NJ 07204 (908) 259-0566
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240 W Sumner Ave APT 38, Roselle Park, NJ 07204 (908) 259-0566
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Pittsburgh, PA
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Kingston, RI
Publications
Us Patents
Cationic Lipids For Nuclei Acid Delivery
View pageUS Patent:
20050084522, Apr 21, 2005
Filed:
Oct 15, 2003
Appl. No.:
10/686262
Inventors:
Michalakis Savva - Roselle Park NJ, US
International Classification:
A61K048/00
A61K009/127
C12N015/74
A61K009/127
C12N015/74
US Classification:
424450000, 435488000, 514044000, 554037000
Abstract:
The invention describes the synthetic methods for a series of pH-sensitive cationic lipids with diamido linkages between the 1,2-diamino-3-propanol backbone and the hydrocarbon chains. Their in vitro biological activity of the resulting lipid-DNA complexes is also described.
Single-Component Ph-Sensitive Liposomes Of Reduced Solid-To-Liquid Phase Transition Temperatures
View pageUS Patent:
20050095280, May 5, 2005
Filed:
Oct 15, 2003
Appl. No.:
10/686374
Inventors:
Michalakis Savva - Roselle Park NJ, US
International Classification:
A61K009/127
C12N015/88
A61K048/00
C12N015/88
A61K048/00
US Classification:
424450000, 435458000, 514044000, 554037000
Abstract:
The current invention relates to the synthesis of novel cationic lipids and their use as delivery vectors for nucleic acids, peptides and other synthetic drugs, in vitro and in vivo. The cationic lipids described herein form stable lamellar structures (liposomes) at physiological pH but destabilize to micelles at acidic and alkaline pH. These structures are characterized of high elasticity, increased fluidity and high transfection activity relative to the corresponding 1,2-dialkyl cationic derivatives and other phospholipids analogues.
Methods And Products For Error Determination Of Drug Dose In Pharmaceutical Mixtures
View pageUS Patent:
20080046188, Feb 21, 2008
Filed:
Aug 18, 2006
Appl. No.:
11/465633
Inventors:
Michalakis Savva - Roselle Park NJ, US
International Classification:
G06F 19/00
US Classification:
702 19, 702 22
Abstract:
The present invention discloses a computer program and a method including an algorithm for computing the uncertainty of drug concentration in pharmaceutical dosage forms. The invention also provides a computer system, a website and an IC chip incorporating the program product. The invention determines the allowable sensitivity of the instruments measuring each of the components and the least allowable weight (LAW) within a maximum allowable error of each ingredient at the predetermined assay standard. The method and products allow the accurate error evaluation of drug dose in pharmaceutical mixtures and unit dosage forms, which may be composed of an infinite number of ingredients that are measured on multiple equipments of variable sensitivities. Thus this invention provides instant guidance on the pharmaceutical ingredient preparation.