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Michele P Calos

from Menlo Park, CA
Age ~73
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Also known as:
Michele Pamela Calos, Michele N Calos, Michelle P Calos, Michele P Ellis
Phone and address:
520 Gilbert Ave, Menlo Park, CA 94025
(650) 384-6115
Related to:
Peter Ellis, 27Thomas HuntEugene WhitneyMarilyn R Whitney, 92Amber Jimenez, 44
Connected to:
Cynthia M Calos, 49Norresa E Calos, 50Olga M Calos, 55Marcia J Calosio, 72Ugo Calosso, 67Evelyn A Caloud, 98Casey J Calouette, 44Jacob Calouette, 39Diana L Calouro, 35Annallee S Calove, 66

Michele Calos Phones & Addresses

  • 520 Gilbert Ave, Menlo Park, CA 94025 (650) 384-6115
  • 1491 Benito Ave, Burlingame, CA 94010
  • 241 Santa Teresa St, Stanford, CA 94305 (650) 838-0910
  • Redwood City, CA
  • San Mateo, CA

Work

Company: American society of gene & cell therapy May 2018 to May 2019 Position: President

Education

Degree: Doctorates, Doctor of Philosophy School / High School: Harvard University Specialities: Molecular Biology, Biochemistry

Skills

Genetics • Biochemistry • Molecular Biology • Cell • Dna • Stem Cells • Cell Biology • Lifesciences • Biotechnology • Gene Therapy • Genomics • Cell Culture • Dna Sequencing • Research • Laboratory • Life Sciences • Science • Drug Discovery • Bioinformatics • Western Blotting • Animal Models • Protein Chemistry • Immunology • Immunohistochemistry • Sequencing • Pcr • Neuroscience • Qpcr • Protein Expression • Physiology • Cancer • Microscopy • Flow Cytometry • Confocal Microscopy • Scientific Writing • Elisa • Tissue Culture • Higher Education • In Vivo • Translational Research • Molecular Genetics • Protein Purification • In Vitro • Cancer Research • Immunofluorescence • Proteomics • Fluorescence Microscopy • Virology • Molecular Cloning • Developmental Biology

Languages

French • Spanish • Greek • English

Industries

Higher Education

Resumes

Resumes

Michele Calos Photo 1

Professor

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Location:
520 Gilbert Ave, Menlo Park, CA 94025
Industry:
Higher Education
Work:
American Society of Gene & Cell Therapy May 2018 - May 2019
President
Pain Therapeutics, Inc. 2007 - 2011
Consultant
Stanford University 2007 - 2011
Professor
Education:
Harvard University
Doctorates, Doctor of Philosophy, Molecular Biology, Biochemistry University of Oxford
Bachelors, Bachelor of Arts, Zoology University of Geneva
Skills:
Genetics
Biochemistry
Molecular Biology
Cell
Dna
Stem Cells
Cell Biology
Lifesciences
Biotechnology
Gene Therapy
Genomics
Cell Culture
Dna Sequencing
Research
Laboratory
Life Sciences
Science
Drug Discovery
Bioinformatics
Western Blotting
Animal Models
Protein Chemistry
Immunology
Immunohistochemistry
Sequencing
Pcr
Neuroscience
Qpcr
Protein Expression
Physiology
Cancer
Microscopy
Flow Cytometry
Confocal Microscopy
Scientific Writing
Elisa
Tissue Culture
Higher Education
In Vivo
Translational Research
Molecular Genetics
Protein Purification
In Vitro
Cancer Research
Immunofluorescence
Proteomics
Fluorescence Microscopy
Virology
Molecular Cloning
Developmental Biology
Languages:
French
Spanish
Greek
English

Business Records

Name / Title
Company / Classification
Phones & Addresses
Michele Calos
Poetic Genetics, LLC
Biotechnology R & D · Biotechnology Research & Development
1700 Owens St, San Francisco, CA 94158
1 Market St, San Francisco, CA 94105

Publications

Us Patents

Methods And Compositions For Genomic Modification

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US Patent:
6632672, Oct 14, 2003
Filed:
Aug 19, 1999
Appl. No.:
09/377885
Inventors:
Michele P. Calos - Woodside CA
Assignee:
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:
C12N 1587
US Classification:
435462, 4353201, 435325, 435465
Abstract:
The present invention provides methods of site-specifically integrating a polynucleotide sequence of interest in a genome of a eucaryotic cell, as well as, enzymes, polypeptides, and a variety of vector constructs useful therefore. In the method, a targeting construct comprises, for example, (i) a first recombination site and a polynucleotide sequence of interest, and (ii) a site-specific recombinase, which are introduced into the cell. The genome of the cell comprises a second recombination site. Recombination between the first and second recombination sites is facilitated by the site-specific recombinase. The invention describes compositions, vectors, and methods of use thereof, for the generation of transgenic cells, tissues, plants, and animals. The compositions, vectors, and methods of the present invention are also useful in gene therapy techniques.

Altered Recombinases For Genome Modification

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US Patent:
6808925, Oct 26, 2004
Filed:
Feb 16, 2001
Appl. No.:
09/788297
Inventors:
Michele P. Calos - Woodside CA
Assignee:
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:
C12N 1590
US Classification:
435462, 435183, 4353201
Abstract:
The present invention describes methods of identifying altered recombinases and compositions thereof, wherein at least one amino acid is different from a parent, wild-type recombinase and the altered recombinase has improved recombination efficiency towards wild-type and/or pseudo att site sequences relative to the parent, wild-type recombinase. The present invention also includes methods of modifying the genomes of cells using the altered recombinases, including methods of site-specifically integrating a polynucleotide sequence of interest in a genome of a eucaryotic cell.

Altered Recombinases For Genome Modification

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US Patent:
7141426, Nov 28, 2006
Filed:
Apr 29, 2004
Appl. No.:
10/836323
Inventors:
Michele P. Calos - Burlingame CA, US
Assignee:
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:
C12N 115/90
C12N 15/63
US Classification:
435462, 4353201
Abstract:
The present invention describes methods of identifying altered recombinases and compositions thereof, wherein at least one amino acid is different from a parent, wild-type recombinase and the altered recombinase has improved recombination efficiency towards wild-type and/or pseudo att site sequences relative to the parent, wild-type recombinase. The present invention also includes methods of modifying the genomes of cells using the altered recombinases, including methods of site-specifically integrating a polynucleotide sequence of interest in a genome of a eucaryotic cell.

Altered Recombinases For Genome Modification

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US Patent:
7732585, Jun 8, 2010
Filed:
Oct 17, 2006
Appl. No.:
11/582836
Inventors:
Michele Pamela Calos - Burlingame CA, US
Assignee:
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:
C07H 21/04
C12N 15/52
C12N 15/63
US Classification:
536 232, 4353201
Abstract:
The present invention describes methods of identifying altered recombinases and compositions thereof, wherein at least one amino acid is different from a parent, wild-type recombinase and the altered recombinase has improved recombination efficiency towards wild-type and/or pseudo att site sequences relative to the parent, wild-type recombinase. The present invention also includes methods of modifying the genomes of cells using the altered recombinases, including methods of site-specifically integrating a polynucleotide sequence of interest in a genome of a eucaryotic cell.

Hybrid Recombinases For Genome Manipulation

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US Patent:
7842503, Nov 30, 2010
Filed:
Apr 29, 2005
Appl. No.:
11/547371
Inventors:
Michele P. Calos - Burlingame CA, US
Assignee:
Poetic Genetics, LLC - Burlingame CA
International Classification:
C12N 15/00
C12N 15/87
C12N 9/00
C12P 21/06
C12P 19/34
C07H 21/04
A61K 38/43
US Classification:
435440, 435455, 435462, 435 691, 4353201, 435 911, 435183, 536 232, 424 941
Abstract:
The present invention provides methods to site-specifically manipulate genomes by using hybrid recombinases. Hybrid recombinases comprise a modified catalytic domain from a unidirectional serine phage integrase, fused to a foreign DNA recognition domain.

Ocular Gene Therapy Using Avalanche-Mediated Transfection

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US Patent:
8101169, Jan 24, 2012
Filed:
Aug 15, 2006
Appl. No.:
11/505249
Inventors:
Mark Blumenkranz - Portola Valley CA, US
Daniel V. Palanker - Sunnyvale CA, US
Alexander Vankov - Menlo Park CA, US
Philip Huie, Jr. - Cupertino CA, US
Michael F. Marmor - Stanford CA, US
Michele P. Calos - Burlingame CA, US
Assignee:
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:
A61K 48/00
US Classification:
424 932, 424 9321
Abstract:
The present invention provides a method of treating an ocular disease in a subject. In a first step, a nucleic acid is introduced into cells or a tissue. The nucleic acid is introduced by electron avalanche transfection. With this technique, a high electric field induces a vapor bubble and plasma discharge between an electrode and the surrounding medium. The formation of a vapor bubble generates mechanical stress. Plasma discharge through the ionized vapor in the bubble enables connectivity between the electrode and the surrounding medium, so that mechanical stress and electric field are applied simultaneously, which results in permeabilization of the cells or tissue. This permeabilization in turn allows the nucleic acid to enter the cell or tissue. Cells or tissue containing the nucleic acid are then transplanted into an ocular region of the subject.

Methods And Compositions For Genomic Modification

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US Patent:
8227249, Jul 24, 2012
Filed:
Apr 2, 2008
Appl. No.:
12/061580
Inventors:
Michele P. Calos - Woodside CA, US
Assignee:
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:
C12N 15/87
US Classification:
435462
Abstract:
The present invention provides methods of site-specifically integrating a polynucleotide sequence of interest in a genome of a eucaryotic cell, as well as, enzymes, polypeptides, and a variety of vector constructs useful therefore. In the method, a targeting construct comprises, for example, (i) a first recombination site and a polynucleotide sequence of interest, and (ii) a site-specific recombinase, which are introduced into the cell. The genome of the cell comprises a second recombination site. Recombination between the first and second recombination sites is facilitated by the site-specific recombinase. The invention describes compositions, vectors, and methods of use thereof, for the generation of transgenic cells, tissues, plants, and animals. The compositions, vectors, and methods of the present invention are also useful in gene therapy techniques.

Methods Of Unidirectional, Site-Specific Integration Into A Genome, Compositions And Kits For Practicing The Same

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US Patent:
8304233, Nov 6, 2012
Filed:
Aug 4, 2005
Appl. No.:
11/198885
Inventors:
Michele P. Calos - Burlingame CA, US
Assignee:
Poetic Genetics, LLC - Burlingame CA
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:
C12N 15/74
C12N 15/63
C12N 15/00
US Classification:
4353201, 536 231, 536 241, 536 242, 435477
Abstract:
The subject invention provides a unidirectional site-specific integration system for integrating a nucleic acid into the genome of a target cell. The provided system includes a site-specific integrating expression cassette (INTEC) vector, consisting of (a) a polynucleotide of interest operably linked to a promoter, (b) a single recombination site, and (c) a hybrid recombination site. In using the subject systems for site-specific integration, the INTEC vector and integrase are introduced into the target cell and the cell is maintained under conditions sufficient to provide for site-specific integration of the nucleic acid into the target cell genome via a recombination event mediated by the site-specific recombinase. Also provided are kits that include the subject systems. The subjects systems, methods and kits find use in a variety of different applications, several representative ones of which are described in detail as well.

Isbn (Books And Publications)

Molecular Evolution of Chromosomes

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Author

Michele Calos

ISBN #

0195099575

Gene Transfer Vectors for Mammalian Cells

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Author

Michele P. Calos

ISBN #

0879691980

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Michele P Calos from Menlo Park, CA, age ~73 Get Report