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Mikhail Y Reibarkh

from Cranford, NJ
Age ~49
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Related to:
Erin A Himelright, 42Brittany Albaugh, 39April D Dearman, 58Elisa Nelsen, 63David Delmastro, 81Mary Delmastro, 77Robert Spearman, 71Robert Spearman, 93
Connected to:
Ian N Reibeisen, 34Brian M Reibel, 44Charles F Reibel, 74Glen C Reibel, 108Donald R Reibeling, 80Hector D Reibeling, 57Carl Reiben, 100Barry W Reiber, 79Jeremiah Reiber, 40Kayla Reiber, 38

Mikhail Reibarkh Phones & Addresses

  • 205 Watchung Ave, Cranford, NJ 07016 (908) 709-8929
  • East Amherst, NY
  • Fremont, CA
  • Somerville, MA
  • Allston, MA
  • Union, NJ
  • Ann Arbor, MI

Publications

Us Patents

Small Molecule Antagonists Of Phosphatidylinositol-3,4,5-Triphosphate (Pip3) And Uses Thereof

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US Patent:
20120136033, May 31, 2012
Filed:
May 17, 2010
Appl. No.:
13/321293
Inventors:
Alexei Degterev - Brookline MA, US
Mikhail Reibarkh - Cranford NJ, US
Gerhard Wagner - Brookline MA, US
Junying Yuan - Newton MA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
Tufts University - Boston MA
International Classification:
A61K 31/426
A61P 35/00
C12N 5/071
A61K 31/17
B82Y 5/00
US Classification:
514369, 435375, 514584, 977773, 977915
Abstract:
Disclosed are a new class of non-lipid small molecule inhibitors which interfere with the interaction between PIP3 and pleckstrin homology domains. These molecules target a broad range of PIP3-dependent signaling events in vitro and exert significant anti-tumor activity in vivo. The small molecule inhibitors of the invention can be used alone or together with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) or other cancer medicament to treat cancer. Small molecule inhibitors of the invention act synergistically in combination with TRAIL in treating cancer. Pharmaceutical compositions and methods for treating cancer are provided.

Process For The Preparation Of Tert-Butyl 4-((2S,5R)-6-(Benzyloxy)-7-Oxo-1,6-Diazabicyclo[3.2.1]Octane-2-Carboxamido)Piperidine-1-Carboxylate And Analogs Thereof

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US Patent:
20170362233, Dec 21, 2017
Filed:
Nov 30, 2015
Appl. No.:
15/532788
Inventors:
- Rahway NJ, US
Nobuyoshi Yasuda - Mountainside NJ, US
Lu Yang - San Diego CA, US
Artis Klapars - Edison NJ, US
Kevin R. Campos - Berkeley Heights NJ, US
Mikhail Reibarkh - Cranford NJ, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
C07D 471/08
C07F 7/18
C07F 7/10
Abstract:
The present invention relates to processes for preparing compounds of Formula I. Such compounds include intermediates in the manufacture of 7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide beta-lactamase inhibitors such as (2S,5R)-7-oxo-N-5 piperidin-4-yl-6-(sulfoxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide. The present invention also relates to novel intermediates formed i these processes. The present invention relates to a process for preparing a compound of Formula I or a pharmaceutically acceptable salt thereof.

Process For Making Chloro-Substituted Nucleoside Phosphoramidate Compounds

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US Patent:
20170226146, Aug 10, 2017
Filed:
Feb 8, 2017
Appl. No.:
15/427674
Inventors:
John Y.L. Chung - Edison NJ, US
Amude Kassim - Rahway NJ, US
John Limanto - Jersey City NJ, US
Michael Shevlin - Middlesex NJ, US
Peter E. Maligres - Fanwood NJ, US
Daniel A. DiRocco - Lebanon NJ, US
James F. Dropinski - Freehold NJ, US
Rose Mathew - Ringoes NJ, US
Yi Ning Ji Chen - Rahway NJ, US
Edward C. Sherer - Hillsborough NJ, US
Mikhail Reibarkh - Cranford NJ, US
Artis Klapars - Edison NJ, US
Alan Hyde - Rahway NJ, US
Susan L. Zultanski - Brooklyn NY, US
Aaron Moment - New York NY, US
Bryon Simmons - Hamilton NJ, US
Tyler A. Davis - Westfield NJ, US
Timothy James Wright - Clark NJ, US
Ralph Calabria - East Brunswick NJ, US
Louis Charles Campeau - Morris Plains NJ, US
International Classification:
C07H 19/10
C07H 19/24
C07D 487/04
C07H 19/06
Abstract:
The present invention is directed to a process for making Chloro-Substituted Nucleoside Phosphoramidate Compounds of formula (I):which are useful for the treatment and prophylaxis of HCV infection. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).
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Mikhail Y Reibarkh from Cranford, NJ, age ~49 Get Report