Min Jung Park

7459475, Dec 2, 2008

Nov 10, 2004

10/985592

Min K. Park - Whippany NJ, US
Prasun K. Chakravarty - Edison NJ, US
Bishan Zhou - Hoboken NJ, US
Edward Gonzalez - Iselin NJ, US
Hyun Ok - Colonia NJ, US
Brenda Palucki - Hillsborough NJ, US
William H. Parsons - Belle Mead NJ, US
Rosemary Sisco - Old Bridge NJ, US

Merck & Co. Inc. - Rahway NJ

A61K 31/41
C07D 249/08

514383, 5482622

Substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, migraine, headache pain, migraine headache, epilepsy, irritable bowel syndrome, diabetic neuropathy, multiple sclerosis, manic depression and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.

20090074890, Mar 19, 2009

Nov 5, 2004

10/578950

Min K. Park - Whippany NJ, US
Prasun K. Chakravarty - Edison NJ, US
Bishan Zhou - Hoboken NJ, US
Edward Gonzalez - Iselin NJ, US
Hyun Ok - Colonia NJ, US
Brenda Palucki - Hillsborough NJ, US
William H. Parsons - Belle Mead NJ, US
Rosemary Sisco - Old Bridge NJ, US
Michael H. Fisher - Ringoes NJ, US

C07D 249/08
A61P 29/00
A61P 9/00
A61P 25/00
A61K 33/00
A61K 31/4196
A61P 1/00
A61P 31/12
A61P 37/00

424722, 5482668, 514383

Substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, migraine, headache pain, migraine headache, epilepsy, irritable bowel syndrome, diabetic neuropathy, multiple sclerosis, manic depression and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier (I), (II), (III).

20130317057, Nov 28, 2013

Jul 20, 2011

13/811059

Scott B. Hoyt - Hoboken NJ, US
Min K. Park - Whippany NJ, US
Clare London - Chattam NJ, US
Yusheng Xiong - Plainsboro NJ, US
D. Jonathan Bennett - Aberdour, GB
Jaiqiang Cai - Glasgow, GB
Paul Ratcliffe - Strathaven, GB
Andrew Cooke - East Kilbride, GB
Emma Carswell - Eaglesham, GB
John MacLean - Kilmamock, GB
Rohit Saxena - Uttar Pradesh, IN
Bheemashankar A. Kulkarni - Karnataka State, IN
Archana Gupta - Uttar Pradesh, IN

C07D 401/04
C07D 413/14
A61K 31/4375
A61K 31/4709
A61K 31/4439
C07D 471/04

514300, 5462734, 514338, 546122, 546144, 514314, 5462721

The invention involves compounds of structural Formula (I) and the pharmaceutically acceptable salts thereof. The compounds of the invention are effective at selectively inhibiting CYP11B2, and are therefore useful for the treatment or prophylaxis of disorders that are associated with elevated aldosterone levels, including, but not limited to, hypertension and heart failure.