Nathalie C Bellocq

7166302, Jan 23, 2007

Dec 19, 2001

10/021294

Suzie Hwang Pun - Torrance CA, US
Hector Gonzalez - San Francisco CA, US
Mark E. Davis - Pasadena CA, US
Nathalie Bellocq - Altadena CA, US
Jianjun Cheng - San Gabriel CA, US

California Institute of Technology - Pasadena CA

A61K 9/14
A61K 31/74
C12P 19/30
C12N 15/63

424486, 4242801, 424489, 424467, 424499, 435 6, 435 691, 435 72, 435455, 435458, 514 44, 514 54

The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent.

7807198, Oct 5, 2010

Dec 28, 2005

11/321441

Suzie Hwang Pun - Torrance CA, US
Hector Gonzalez - San Francisco CA, US
Mark E. Davis - Pasadena CA, US
Nathalie C. Bellocq - Altadena CA, US
Jianjun Cheng - Arcadia CA, US

California Institute of Technology - Pasadena CA
Calando Pharmaceuticals, Inc. - Pasadena CA

A61K 9/14
A61K 31/74

424486, 4242801, 424489, 424467, 424499

The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent.

7968123, Jun 28, 2011

Oct 25, 2006

11/588033

Suzie Hwang Pun - Torrance CA, US
Hector Gonzalez - San Francisco CA, US
Mark E. Davis - Pasadena CA, US
Nathalie C. Bellocq - Altadena CA, US
Jianjun Cheng - Arcadia CA, US

California Institute of Technology - Pasadena CA
Calando Pharmaceuticals, Inc. - Pasadena CA

A61K 31/74
A61K 9/14
C12P 19/30
C12N 15/63

424486, 4242801, 424489, 424467, 424499, 435 6, 435 691, 435 72, 435455, 435458, 514 54

The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent.

8092833, Jan 10, 2012

Jul 29, 2010

12/846344

Suzie Hwang Pun - Torrance CA, US
Hector Gonzalez - San Francisco CA, US
Mark E. Davis - Pasadena CA, US
Nathalie C. Bellocq - Altadena CA, US
Jianjun Cheng - Arcadia CA, US

California Institute of Technology - Pasadena CA
Calando Pharmaceuticals, Inc. - Pasadena CA

A61K 31/74
A61K 9/14
C12P 19/30
C12N 15/63

424486, 4242801, 424489, 424467, 424499, 435 691, 435 72, 435455, 435485

The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent.

8277846, Oct 2, 2012

May 13, 2011

13/107024

Suzie Hwang Pun - Torrance CA, US
Hector Gonzalez - San Francisco CA, US
Mark E. Davis - Pasadena CA, US
Nathalie C. Bellocq - Altadena CA, US
Jianjun Cheng - Arcadia CA, US

California Institute of Technology - Pasadena CA
Calando Pharmaceuticals, Inc. - Pasadena CA

A61K 31/74
A61K 9/14
C12P 19/30
C12N 15/63

424486, 4242801, 424489, 424499, 435 72, 435458, 514 54

The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent.

8357377, Jan 22, 2013

Oct 8, 2003

10/681745

Suzie Hwang Pun - Torrance CA, US
Nathalie C. Bellocq - Altadena CA, US
Mark E. Davis - Pasadena CA, US

A61K 9/00
A61K 39/395
A61K 45/00
A01N 59/00

424400, 424600, 4241721, 4242781

This application discloses cyclodextrin-modified materials for carrying drugs and other active agents, such as nucleic acids. Compositions are also disclosed of cyclodextrin-modified materials that release such active agents under controlled conditions. The invention also discloses compositions of cyclodextrin-modified polymer carriers that are coupled to biorecognition molecules for assisting the delivery of drugs to their site of action.

20030008818, Jan 9, 2003

Dec 19, 2001

10/021312

Suzie Pun - Torrance CA, US
Hector Gonzalez - San Francisco CA, US
Mark Davis - Pasadena CA, US
Nathalie Bellocq - Altadena CA, US
Jianjun Cheng - San Gabriel CA, US

California Institute of Technology and Insert Therapeutics, Inc

A61K038/16
A61K031/715
A61K031/66
C07K014/00
C08B037/00
A61K031/165

514/012000, 514/054000, 514/129000, 514/623000, 530/406000, 536/053000, 558/194000, 564/152000, 564/188000

The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:

20040087024, May 6, 2004

Feb 24, 2003

10/372723

Nathalie Bellocq - Altadena CA, US
Jianjun Cheng - Arcadia CA, US
Mark Davis - Pasadena CA, US
Suzie Pun - Torrance CA, US

Insert Therapeutics, Inc. - Pasadena CA

A61K048/00
C08G063/48
C08G063/91
C12N015/85
A61K031/795

435/455000, 525/054200, 514/044000, 424/078300

This application discloses compositions of carbohydrate-modified polymers, such as polyethylenimine modified with cyclodextrin moieties, for carrying drugs and other active agents, such as nucleic acids. Compositions are also disclosed of carbohydrate-modified polymer carriers that release such agents under controlled conditions. The invention also discloses compositions of carbohydrate-modified polymer carriers that are coupled to biorecognition molecules for targeting the delivery of drugs to their site of action.