US Patent:
20110038855, Feb 17, 2011
Inventors:
Stephen P. Schoenberger - Encinitas CA, US
Douglas R. Green - Germantown TN, US
Edith M. Janssen - San Diego CA, US
Nathalie M. Droin - Memphis TN, US
Assignee:
LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY - La Jolla CA
International Classification:
A61K 39/395
C12N 5/0783
A61P 37/00
A61P 25/00
US Classification:
4241331, 4353723, 4241731, 4241441
Abstract:
Methods of modulating a T cell response are provided. Methods include, among other things, contacting a T cell that expresses TNF-related apoptosis-inducing ligand (TRAIL, Apo-2L) or TRAIL receptor (DR4 or DR5) with a molecule that binds to TRAIL (Apo-2L), a molecule that binds to TRAIL receptor (DR4 or DR5), or with a soluble TRAIL (Apo-2L) reagent.