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Paul J Muchowski

from San Francisco, CA
Age ~53
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Related to:
Karen Elizabet Muchowski, 55Zhiming LiuWilliam R ArbanDiana M Arban, 49Joseph M Muchowski, 87Kim T Tran, 81Cecile Tran, 54Theresa T Thao, 49Bich Ngoc Tran, 54Hai Thuong Tran, 81Bao Ngoc Tran, 52Suong H Do, 54Cecile C Tashima, 51Judith C Muchowski, 81Robert A Arban, 49
Connected to:
Fairuz Muchtar, 49Morales O Mucia, 34Edward J Mucic, 32Violet Mucic, 66Carolyn R Mucik, 77Andrew A Mucino, 39Efren S Mucino, 49Jaime Y Mucino, 59Rosas R Mucino, 55Daniel E Mucinskas, 34

Paul Muchowski Phones & Addresses

  • 634 Los Palmos Dr, San Francisco, CA 94127
  • 3883 23Rd St, San Francisco, CA 94114 (415) 814-2238
  • 195 Beacon St, San Francisco, CA 94131
  • 1720 Banff Dr, Sunnyvale, CA 94087 (408) 733-8164
  • 6219 196Th St, Kenmore, WA 98028
  • 15 Etruria St, Seattle, WA 98119 (206) 281-4036
  • 15 W Etruria St #6, Seattle, WA 98119
  • 2234 E Mcgraw St, Seattle, WA 98112
  • Santa Clara, CA

Resumes

Resumes

Paul Muchowski Photo 1

Founder, Ceo, Chief Strategy Officer

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Location:
San Francisco, CA
Industry:
Non-Profit Organization Management
Work:
National Cannabis Industry Association Jun 2017 - Jul 2019
Chair, Scientific Advisory Committee
Www.doctorpauls.co Jun 2017 - Jul 2019
Founder, Ceo, Chief Strategy Officer
Teva Pharmaceuticals Mar 2014 - Jun 2015
Consultant
Kynurex Jan 2012 - Dec 2014
Founder and Acting Chief Executive Officer
Ucsf Jan 2012 - Dec 2014
Professor In Residence, Associate Profesor In Residence
Education:
University of Washington - School of Medicine 1994 - 1998
Doctorates, Doctor of Philosophy, Philosophy Uc San Diego 1988 - 1993
Bachelors, Bachelor of Arts, Bachelor of Science, Microbiology, Political Science
Skills:
Biochemistry
Neuroscience
Cell Biology
Cell
Molecular Biology
Biotechnology
Pharmacology
Drug Discovery
Genetics
Animal Models
Protein Chemistry
Cell Culture
Drug Development
Clinical Trials
Confocal Microscopy
Biophysics
Languages:
Spanish
German
Paul Muchowski Photo 2

Associate Professor At Gladstone Institute Of Neurological Disease And Uc San Francisco

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Location:
San Francisco Bay Area
Industry:
Research

Publications

Us Patents

Drug Targets For The Treatment Of Neurodegenerative Disorders

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US Patent:
7504227, Mar 17, 2009
Filed:
Oct 20, 2004
Appl. No.:
10/970136
Inventors:
Paul J. Muchowski - San Francisco CA, US
Vicente E. Sancenon Galarza - San Francisco CA, US
Assignee:
University of washington - Seattle WA
International Classification:
G01N 33/53
G01N 33/567
C12N 1/19
C12P 19/34
C07K 14/00
C07H 21/04
US Classification:
435 72, 435 71, 435 721, 4352542, 435 9132, 530350, 536 231, 536 234
Abstract:
Methods of screening candidate agents to identify potential therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease, are provided.

Identifying Agents For Decreasing Cellular Toxicity Associated With Huntingin Polypeptide

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US Patent:
7618793, Nov 17, 2009
Filed:
Oct 20, 2004
Appl. No.:
10/970741
Inventors:
Paul J. Muchowski - Sunnyvale CA, US
Flaviano Giorgini - Leicester, GB
Assignee:
The Regents of the University of Washington - Seattle WA
International Classification:
G01N 33/53
C12P 21/06
C12N 15/74
A01N 63/04
A61K 49/00
US Classification:
435 731, 435 699, 435483, 424 9351, 424 91
Abstract:
Methods of screening candidate agents to identify potential therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease, are provided.

Small Molecule Inhibitors Of Kynurenine-3-Monooxygenase

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US Patent:
8071631, Dec 6, 2011
Filed:
Aug 16, 2007
Appl. No.:
11/840145
Inventors:
Paul J. Muchowski - Sunnyvale CA, US
Joseph M. Muchowski - Westbank, CA
Robert Schwarcz - Baltimore MD, US
Paolo Guidetti - Baltimore MD, US
Assignee:
The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone - San Francisco CA
University Of Maryland, Baltimore - Baltimore MD
International Classification:
C07D 285/08
C07D 285/135
A61K 31/433
A61P 25/28
US Classification:
514361, 514363, 548128, 548136
Abstract:
The present invention relates to compounds of Formula I below and their tautomers or pharmaceutically acceptable salts, compositions and methods of uses thereof:.

Methods Of Identifying Agents That Diminish Cellular Toxicity Associated With An Α-Synuclein Polypeptide Of Parkinson's Disease In Yeast

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US Patent:
8133679, Mar 13, 2012
Filed:
Nov 17, 2008
Appl. No.:
12/272031
Inventors:
Paul J. Muchowski - Kenmore WA, US
Susan L. Lindquist - Chestnut Hill MA, US
Tiago Outeiro - Cambridge MA, US
Assignee:
Whitehead Institute for Biomedical Research - Cambridge MA
University of Washington - Seattle WA
International Classification:
C12Q 1/68
G01N 33/53
G01N 33/569
A01N 63/00
A01N 63/04
C07H 21/04
C12N 15/11
US Classification:
435 613, 435375, 435 731, 435 61, 424 935, 536 231, 536 235, 514 44 A
Abstract:
Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease, are provided.

Small Molecule Inhibitors Of Kynurenine-3-Monooxygenase

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US Patent:
8466182, Jun 18, 2013
Filed:
Nov 2, 2011
Appl. No.:
13/287776
Inventors:
Paul J. Muchowski - Sunnyvale CA, US
Joseph M. Muchowski - Westbank, CA
Robert Schwarcz - Baltimore MD, US
Paolo Guidetti - Baltimore MD, US
Assignee:
The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone - San Francisco CA
University of Maryland, Baltimore - Baltimore MD
International Classification:
A61K 31/40
A61K 31/415
A61K 31/4168
A61K 31/4196
A61K 31/421
A61K 31/4245
C07D 207/34
C07D 231/38
C07D 233/88
C07D 249/14
C07D 261/14
C07D 263/48
C07D 271/07
C07D 275/03
C07D 285/135
C07D 285/08
US Classification:
514363, 514364, 514372, 514377, 514378, 514383, 514426, 548214, 548233, 548246, 5482648, 5483311, 5483721, 548128, 548131, 548557
Abstract:
The present invention relates to compounds of Formula I below and their tautomers or pharmaceutically acceptable salts, compositions and methods of uses thereof.

Small Molecule Inhibitors Of Kynurenine-3-Monooxygenase

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US Patent:
7994338, Aug 9, 2011
Filed:
Aug 16, 2007
Appl. No.:
11/840138
Inventors:
Paul J. Muchowski - Sunnyvale CA, US
Joseph M. Muchowski - Westbank, CA
Robert Schwarcz - Baltimore MD, US
Paolo Guidetti - Baltimore MD, US
Assignee:
The J. David Gladstone Institutes - San Francisco CA
University Of Maryland, Baltimore - Baltimore MD
International Classification:
A61K 31/427
C07D 277/44
C07D 417/06
US Classification:
548197, 5142278, 5142368, 51425404, 514326, 514370, 544 60, 544133, 544367, 546209
Abstract:
The present invention relates to compounds of formula Ia or Ib below and their tautomers and/or pharmaceutically acceptable salts and compositions and methods of uses thereof.

Methods Of Identifying Lead Compounds That Modulate Toxicity Of Neurotoxic Polypeptides

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US Patent:
20050255450, Nov 17, 2005
Filed:
Dec 3, 2004
Appl. No.:
11/003216
Inventors:
Paul Muchowski - Kenmore WA, US
Susan Lindquist - Chestnut Hill MA, US
Tiago Outeiro - Cambridge MA, US
Assignee:
University of Washington - Seattle WA
Whitehead Institute for Biomedical Research - Cambridge MA
International Classification:
C12Q001/00
C12Q001/68
C12N001/18
US Classification:
435004000, 435006000, 435254210
Abstract:
Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease, are provided.

Non-Invasive Methods And Related Compositions For Identifying Compounds That Modify In Vivo Aggregations Of Disease-Related Polypeptides

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US Patent:
20080168569, Jul 10, 2008
Filed:
Aug 13, 2004
Appl. No.:
10/918708
Inventors:
Paul J. Muchowski - Kenmore WA, US
John I. Clark - Seattle WA, US
International Classification:
G01N 33/00
A01K 67/00
C12N 15/63
US Classification:
800 3, 800 13, 4353201
Abstract:
Embodiments of the present invention are directed to various high-throughput methods for identifying compounds that are useful for the treatment of various neurodegenerative diseases, including the Huntington's Disease (HD), Parkinson's Disease (PD), Alzheimer's Disease (AD), and Amyotrophic Lateral Sclerosis (ALS). Methods and compositions of the present invention enable the exogenous expression of one or more neurodegenerative-disease-related polypeptide variants within the ocular lens of an animal host. The formation of aggregates containing neurodegenerative-disease-related polypeptide variants increases the opacity of the lens, in a manner similar to the development of age-onset cataracts. The effect of a test compound in decreasing aggregate formation and/or destabilizing aggregates that contain neurodegenerative-disease-related polypeptide variants can be visually monitored and quantified in living animal hosts by employing conventional cataract-detecting instrumentation and related methods.
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Paul J Muchowski from San Francisco, CA, age ~53 Get Report