Inventors:
Roland Dolle - King of Prussia PA, US
Bertrand Le Bourdonnec - East Fallowfield PA, US
Christopher Ajello - Lansdale PA, US
Minghua Gu - Collegeville PA, US
Guo-Hua Chu - Wilmington DE, US
Paul Tuthill - Newark DE, US
Lara Leister - Shillington PA, US
Assignee:
Adolor Corporation - Exton PA
International Classification:
A61K 47/00
A61K 31/407
A61K 31/4433
A61K 31/496
A61P 25/00
A61P 25/28
A61P 27/06
A61P 9/06
C07D 241/04
C07D 491/052
C07D 273/01
C07D 211/26
A61P 41/00
A61P 25/30
A61P 25/04
A61P 15/12
A61K 31/5355
A61K 31/55
US Classification:
424009100, 514212020, 514233500, 514253030, 514278000, 514409000, 540543000, 544230000, 544070000, 546017000, 548409000
Abstract:
Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other δ opioid receptor-mediated conditions.