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Rachel N Maccoss

from Johns Island, SC
Age ~45
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Related to:
Jian Jun Chen, 62Yanxia Xu, 63Huey F WuAlexander Wu, 48Steven Falcone, 57Young S Moon, 81Mari A Falcone
Connected to:
Pedro J Maccou, 71Alisha J Maccoux, 38Cathy A Maccoux, 63Daniel A Maccoux, 63Vincent J Maccoux, 87Dyan L Maccowan, 53Victor Maccow, 33James H Maccoy, 93John M Maccoy, 34Minnetta D Maccoy, 100

Rachel Maccoss Phones & Addresses

  • 2556 Seabrook Island Rd, Johns Island, SC 29455 (609) 213-9752
  • 90 Marion St, Brookline, MA 02446
  • 90 Marion St #2, Brookline, MA 02446
  • 48 Rose Ct, Freehold, NJ 07728
  • Plainsboro, NJ
  • Princeton, NJ
  • Burlington, VT
  • 2556 Seabrook Island Rd, Johns Island, SC 29455

Work

Company: University of oxford Jan 2012 Position: Research facilitator for chemical biology

Education

Degree: PhD School / High School: University of Cambridge 2001 to 2004 Specialities: Organic Chemistry

Industries

Research

Resumes

Resumes

Rachel Maccoss Photo 1

Research Facilitator At University Of Oxford

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Position:
Research Facilitator for Chemical Biology at University of Oxford
Location:
Oxford, United Kingdom
Industry:
Research
Work:
University of Oxford since Jan 2012
Research Facilitator for Chemical Biology
Merck Jul 2007 - Jul 2011
Senior Research Chemist
Princeton University Mar 2005 - Apr 2007
Post-Doctoral Researcher
National Academy of Sciences - Washington D.C. Metro Area Sep 2004 - Nov 2004
Christine Mirzayan Science and Technology Policy Graduate Fellow
Education:
University of Cambridge 2001 - 2004
PhD, Organic Chemistry University of Vermont 1997 - 2001
BSc, Chemistry

Publications

Us Patents

Inhibitors Of Janus Kinases

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US Patent:
8344144, Jan 1, 2013
Filed:
Jun 8, 2009
Appl. No.:
12/999342
Inventors:
Michelle Machacek - Brookline MA, US
Gabriela de Almeida - Brookline MA, US
Jonathan B. Grimm - Newton MA, US
Rachel N. MacCoss - Brookline MA, US
Eric Romeo - Allston MA, US
Tony Siu - Brookline MA, US
Catherine White - Newton Center LA, US
Kevin Wilson - West Newton MA, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
C07D 471/02
A61K 31/395
US Classification:
546113, 514300
Abstract:
The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3, TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.

Inhibitors Of Janus Kinases

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US Patent:
8367706, Feb 5, 2013
Filed:
Jun 16, 2008
Appl. No.:
12/665045
Inventors:
Michael Altman - Cambridge MA, US
Matthew Christopher - Wallingford CT, US
Jonathan B. Grimm - Newton MA, US
Andrew Haidle - Cambridge MA, US
Kaleen Konrad - Newton MA, US
Jongwon Lim - Lexington MA, US
Rachel N. MacCoss - Brookline MA, US
Michelle Machacek - Brookline MA, US
Ekundayo Osimboni - Ashland MA, US
Ryan D. Otte - Natick MA, US
Tony Siu - Brookline MA, US
Kerrie Spencer - Woonsocket RI, US
Brandon Taoka - Allston MA, US
Paul Tempest - Brookline MA, US
Kevin Wilson - West Newton MA, US
Hyun Chong Woo - Brookline MA, US
Jonathan Young - Southborough MA, US
Anna Zabierek - Salem MA, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
A61K 31/4436
C07D 409/12
US Classification:
514336, 5462814
Abstract:
The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.

Therapeutic Compounds

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US Patent:
8455477, Jun 4, 2013
Filed:
Jul 27, 2009
Appl. No.:
13/057325
Inventors:
Jason Katz - Newton Highlands MA, US
James Jewell - Somerville MA, US
Joon Jung - Newton MA, US
Solomon Kattar - Arlington MA, US
Yongquan Hou - Cambridge MA, US
Rachel MacCoss - Brookline MA, US
Satoru Ito - Tsukuba, JP
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
MSD K.K. - Tokyo
International Classification:
A61K 31/437
A61K 31/438
A61K 31/4439
A61K 31/444
A61K 31/5377
A61K 31/397
A61K 31/505
A61K 31/495
A61K 31/496
A61K 31/50
C07F 7/02
C07D 487/02
C07D 413/14
C07D 401/02
C07D 401/14
C07D 221/20
US Classification:
51421018, 5142332, 5142355, 51425201, 51425213, 51425505, 514256, 514278, 514300, 544124, 544127, 544238, 544333, 544360, 544362, 544405, 546 14, 546 15, 546 16, 546121
Abstract:
The present invention relates to pyrazolopyridines and imidazopyridines which are inhibitors of the kinase PDK1 and are thus useful for the treatment of myeloproliferative disorders or cancer. The compounds are also useful as inhibitors of other kinases such as FGFR3, NTRK3, RP-S6K and WEE1. Furthermore, the present compounds also selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of Alzheimer's disease.

Triazole Derivatives For Treatment Of Alzheimer's Disease

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US Patent:
8575150, Nov 5, 2013
Filed:
Dec 7, 2009
Appl. No.:
13/139830
Inventors:
Christian Fischer - Natick MA, US
Joey Methot - Westwood MA, US
Hua Zhou - Acton MA, US
Adam J. Schell - Newton MA, US
Benito Munoz - Cambridge MA, US
Alexey A. Rivkin - Boston MA, US
Sean P. Ahearn - Somerville MA, US
Stephanie Chichetti - Brooklyn NY, US
Rachel N. MacCoss - Brookline MA, US
Sam Kattar - Arlington MA, US
Matthew Christopher - Brookline MA, US
Chaomin Li - Boston MA, US
Andrew Rosenau - Cambridge MA, US
William Colby Brown - Cleveland Heights OH, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
C07D 249/14
A61K 31/4196
US Classification:
51421207, 540523
Abstract:
According to the invention there is provided a compound of formula I or a pharmaceutically acceptable salt or hydrate thereof; wherein the variables are as defined herein. The compounds selectively attenuate the production of Aβ42 and hence are useful in treatment of Alzheimer's disease and related conditions.

Inhibitors Of Janus Kinases And/Or 3-Phosphoinositide-Dependent Protein Kinase-1

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US Patent:
20100160309, Jun 24, 2010
Filed:
Mar 10, 2008
Appl. No.:
12/530648
Inventors:
Tony Siu - Brookline MA, US
Jonathan Young - Southborough MA, US
Micheal Altman - Cambridge MA, US
Alan Northrup - Reading MA, US
Ekaterina Kozina - Evanston IL, US
Christopher Dinsmore - Newton MA, US
David J. Guerin - Natick MA, US
Kevin A. Keenan - Newton MA, US
Joon O. Jung - Newton MA, US
Solomon Kattar - Arlington MA, US
Rachel N. MacCoss - Brookline MA, US
International Classification:
A61K 31/4375
C07D 471/04
C07D 471/14
A61P 35/00
A61K 31/5377
A61K 31/501
A61K 31/506
US Classification:
5142328, 546 88, 546 82, 544126, 544238, 544333, 514292, 514293, 51425204, 514256
Abstract:
The instant invention provides for compounds that inhibit JAK2 tyrosine kinase and/or PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting JAK2 tyrosine kinase activity and/or PDK1 kinase inhibitory activity by administering the compound to a patient in need of treatment or prevention of myeloproliferative disorders or cancer.

Diaryl Ether Derivatives As Notch Sparing Gamma Secretase Inhibitors

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US Patent:
20130053386, Feb 28, 2013
Filed:
Oct 5, 2010
Appl. No.:
13/501628
Inventors:
William Colby Brown - Cleveland Heights OH, US
Richard W. Heidebrecht - Brookline MA, US
Jason Brubaker - Cambridge MA, US
Christian Fischer - Natick MA, US
John T. Hendrix - Charlottesville VA, US
Elizabeth H. Kelley - Lynnfield MA, US
Rachel N. MacCoss - Brookline MA, US
Joey L. Methot - Westwood MA, US
Thomas Miller - Brookline MA, US
Karin M. Otte - Natick MA, US
Phieng Siliphaivanh - Newton MA, US
Thomas Reger - Lansdale PA, US
Peter D. Williams - Harleyville PA, US
Catherine M. Wiscount - Allentown PA, US
International Classification:
C07D 231/20
C07D 403/12
A61K 31/4155
C07D 401/12
A61K 31/4439
A61K 31/454
A61K 31/506
C07D 401/04
C07D 405/12
C07D 413/12
A61K 31/4245
A61K 31/422
A61K 31/5377
C07D 491/113
A61K 31/438
A61K 31/496
C07D 413/14
A61P 25/28
A61K 31/415
US Classification:
5142365, 5483661, 514407, 5483641, 5462761, 514341, 546211, 514326, 544316, 514274, 5483657, 548143, 514364, 548236, 514374, 544140, 546 19, 514278, 544371, 51425405
Abstract:
The invention encompasses a novel class of diaryl ether derivatives which inhibit the processing of APP by the putative γ-secretase while sparing Notch signaling pathway, and thus are useful in the treatment or prevention of Alzheimer's disease without the development of Notch inhibition mediated gastrointestinal issues. Pharmaceutical compositions and methods of use are also included.
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Rachel N Maccoss from Johns Island, SC, age ~45 Get Report