US Patent:
20150169840, Jun 18, 2015
Inventors:
Kenneth Kupfer - Del Mar CA, US
Richard C. Sangeorge - Carlsbad CA, US
Jerome Mcaleer - Minster Lovell, GB
Kevin Keegen - San Diego CA, US
David Kinniburgh Lang - Glasgow, GB
Assignee:
Alere San Diego, Inc. - San Diego CA
International Classification:
G06F 19/00
G01N 33/53
A61B 5/02
Abstract:
The present invention provides methods and compositions for monitoring of subjects suffering from, or being evaluated for, heart failure. A filtered Natriuretic peptide time-series, alone or in combination with other clinical indicia such as weight gain, can be used to estimate a patient's hazard (risk of decompensation). The cumulative integral of Natriuretic peptide concentration can be used to estimate cumulative hazard (risk times exposure) over longer periods of exposure, e.g., 14 day periods, or 30 day periods.